Drug Information
Drug General Information | |||||
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Drug ID |
D0V8PA
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Former ID |
DNC008434
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Drug Name |
NERIDRONIC ACID
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Drug Type |
Small molecular drug
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Indication | Bone disease [ICD10:M00-M99] | Approved | [1] | ||
Structure |
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Download2D MOL |
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Formula |
C6H17NO7P2
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Canonical SMILES |
C(CCC(O)(P(=O)(O)O)P(=O)(O)O)CCN
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InChI |
1S/C6H17NO7P2/c7-5-3-1-2-4-6(8,15(9,10)11)16(12,13)14/h8H,1-5,7H2,(H2,9,10,11)(H2,12,13,14)
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InChIKey |
PUUSSSIBPPTKTP-UHFFFAOYSA-N
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CAS Number |
CAS 79778-41-9
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Farnesyl pyrophosphatesynthetase | Target Info | Inhibitor | [2] | |
KEGG Pathway | Terpenoid backbone biosynthesis | ||||
Metabolic pathways | |||||
Biosynthesis of antibiotics | |||||
Influenza A | |||||
HTLV-I infection | |||||
PathWhiz Pathway | Steroid Biosynthesis | ||||
Reactome | Cholesterol biosynthesis | ||||
Activation of gene expression by SREBF (SREBP) | |||||
WikiPathways | Activation of Gene Expression by SREBP (SREBF) | ||||
SREBP signalling | |||||
Cholesterol Biosynthesis | |||||
References | |||||
REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
REF 2 | J Med Chem. 2008 Apr 10;51(7):2187-95. Epub 2008 Mar 8.Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. | ||||
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