Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0V8PA
|
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| Former ID |
DNC008434
|
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| Drug Name |
NERIDRONIC ACID
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| Drug Type |
Small molecular drug
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| Indication | Bone disease [ICD10:M00-M99] | Approved | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C6H17NO7P2
|
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| Canonical SMILES |
C(CCC(O)(P(=O)(O)O)P(=O)(O)O)CCN
|
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| InChI |
1S/C6H17NO7P2/c7-5-3-1-2-4-6(8,15(9,10)11)16(12,13)14/h8H,1-5,7H2,(H2,9,10,11)(H2,12,13,14)
|
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| InChIKey |
PUUSSSIBPPTKTP-UHFFFAOYSA-N
|
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| CAS Number |
CAS 79778-41-9
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Farnesyl pyrophosphatesynthetase | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Terpenoid backbone biosynthesis | ||||
| Metabolic pathways | |||||
| Biosynthesis of antibiotics | |||||
| Influenza A | |||||
| HTLV-I infection | |||||
| PathWhiz Pathway | Steroid Biosynthesis | ||||
| Reactome | Cholesterol biosynthesis | ||||
| Activation of gene expression by SREBF (SREBP) | |||||
| WikiPathways | Activation of Gene Expression by SREBP (SREBF) | ||||
| SREBP signalling | |||||
| Cholesterol Biosynthesis | |||||
| References | |||||
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
| REF 2 | J Med Chem. 2008 Apr 10;51(7):2187-95. Epub 2008 Mar 8.Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. | ||||
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