| Drug General Information |
| Drug ID |
D0BI3N
|
| Former ID |
DIB006023
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| Drug Name |
Cerdulatinib
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| Synonyms |
PRT-062070; Syk + JAK multikinase inhibitor (NHL/CLL/RA), Portola Pharmaceuticals
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| Indication |
Non-hodgkin's lymphoma [ICD10:C85]
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Phase 1/2 |
[1]
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|---|
| Company |
Portola Pharmaceuticals Inc; portola pharmaceuticals
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| Structure |
|
Download
2D MOL
3D MOL
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| Target and Pathway |
| Target(s) |
Tyrosine-protein kinase JAK2 |
Target Info |
Modulator |
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| Tyrosine-protein kinase SYK |
Target Info |
Modulator |
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KEGG Pathway
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Chemokine signaling pathway
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PI3K-Akt signaling pathway
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Signaling pathways regulating pluripotency of stem cells
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Jak-STAT signaling pathway
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Cholinergic synapse
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Prolactin signaling pathway
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Adipocytokine signaling pathway
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Leishmaniasis
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Toxoplasmosis
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Tuberculosis
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Measles
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Influenza A
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Herpes simplex infectionhsa04064:NF-kappa B signaling pathway
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Osteoclast differentiation
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Platelet activation
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Natural killer cell mediated cytotoxicity
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B cell receptor signaling pathway
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Fc epsilon RI signaling pathway
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Fc gamma R-mediated phagocytosis
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Epstein-Barr virus infection
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Viral carcinogenesis
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PANTHER Pathway
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Inflammation mediated by chemokine and cytokine signaling pathway
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Interferon-gamma signaling pathway
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JAK/STAT signaling pathway
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PDGF signaling pathway
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PI3 kinase pathway
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CCKR signaling map STP00010:B cell activation
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Pathway Interaction Database
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Endothelins
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ErbB4 signaling events
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GMCSF-mediated signaling events
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IL4-mediated signaling events
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IL27-mediated signaling events
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Signaling events mediated by PTP1B
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IL12-mediated signaling events
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S1P3 pathway
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SHP2 signaling
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CXCR4-mediated signaling events
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IL5-mediated signaling events
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IFN-gamma pathway
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ErbB2/ErbB3 signaling events
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IL3-mediated signaling events
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IL6-mediated signaling events
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PDGFR-beta signaling pathway
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IL23-mediated signaling events
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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EPO signaling pathway
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Notch-mediated HES/HEY networkfcer1pathway:Fc-epsilon receptor I signaling in mast cells
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BCR signaling pathway
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Atypical NF-kappaB pathway
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Osteopontin-mediated events
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FAS (CD95) signaling pathway
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Thromboxane A2 receptor signaling
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IL2-mediated signaling events
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Class I PI3K signaling events
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Alpha-synuclein signaling
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PathWhiz Pathway
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Fc Epsilon Receptor I Signaling in Mast Cells
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Reactome
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Interleukin-6 signaling
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MAPK3 (ERK1) activation
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MAPK1 (ERK2) activation
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GPVI-mediated activation cascade
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Prolactin receptor signaling
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RMTs methylate histone arginines
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G beta:gamma signalling through PI3Kgamma
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Interleukin-3, 5 and GM-CSF signaling
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RAF activation
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RAF/MAP kinase cascade
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Interferon gamma signaling
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Regulation of IFNG signaling
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Interleukin receptor SHC signaling
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Growth hormone receptor signaling
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Factors involved in megakaryocyte development and platelet productionR-HSA-114604:GPVI-mediated activation cascade
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FCGR activation
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Regulation of actin dynamics for phagocytic cup formation
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Role of phospholipids in phagocytosis
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DAP12 signaling
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Fc epsilon receptor (FCERI) signaling
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Role of LAT2/NTAL/LAB on calcium mobilization
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FCERI mediated MAPK activation
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FCERI mediated Ca+2 mobilization
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Integrin alphaIIb beta3 signaling
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Interleukin-2 signaling
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CLEC7A (Dectin-1) signaling
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Dectin-2 family
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Regulation of signaling by CBL
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Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
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WikiPathways
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Serotonin Receptor 2 and STAT3 Signaling
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Type II interferon signaling (IFNG)
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Notch Signaling Pathway
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EPO Receptor Signaling
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EGF/EGFR Signaling Pathway
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IL-4 Signaling Pathway
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IL-6 signaling pathway
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Kit receptor signaling pathway
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IL-3 Signaling Pathway
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Mesodermal Commitment Pathway
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Interleukin-2 signaling
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Signaling by SCF-KIT
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Prolactin receptor signaling
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Growth hormone receptor signaling
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JAK/STAT
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BDNF signaling pathway
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Oncostatin M Signaling Pathway
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Interleukin-11 Signaling Pathway
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AGE/RAGE pathway
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TSLP Signaling Pathway
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IL17 signaling pathway
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Leptin signaling pathway
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TSH signaling pathway
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Interleukin-3, 5 and GM-CSF signaling
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Interferon gamma signaling
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Factors involved in megakaryocyte development and platelet production
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IL-5 Signaling PathwayWP49:IL-2 Signaling Pathway
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Fc epsilon receptor (FCERI) signaling
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Signaling by the B Cell Receptor (BCR)
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Fcgamma receptor (FCGR) dependent phagocytosis
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DAP12 interactions
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B Cell Receptor Signaling Pathway
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RANKL/RANK Signaling Pathway
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Integrin alphaIIb beta3 signaling
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GPVI-mediated activation cascade
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Regulation of toll-like receptor signaling pathway
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IL-5 Signaling Pathway
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| References |
| REF 1 | Clinical pipeline report, company report or official report of Portola. |
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