Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00LNW
|
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| Former ID |
DIB005469
|
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| Drug Name |
KPT-330
|
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| Drug Type |
Small molecular drug
|
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| Indication | Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] | Phase 2 | [1] | ||
| Company |
Karyopharm therapeutics
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C17H11F6N7O
|
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| Canonical SMILES |
C1=CN=C(C=N1)NNC(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)<br />F)C(F)(F)F
|
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| InChI |
1S/C17H11F6N7O/c18-16(19,20)11-5-10(6-12(7-11)17(21,22)23)15-26-9-30(29-15)4-1-14(31)28-27-13-8-24-2-3-25-13/h1-9H,(H,25,27)(H,28,31)/b4-1-
|
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| InChIKey |
DEVSOMFAQLZNKR-RJRFIUFISA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Drug Resistance Mutation (DRM) | |||||
| DRM | DRM Info | ||||
| Target and Pathway | |||||
| Target(s) | Exportin-1 | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Ribosome biogenesis in eukaryotes | ||||
| RNA transport | |||||
| Influenza A | |||||
| HTLV-I infection | |||||
| Epstein-Barr virus infection | |||||
| Pathway Interaction Database | Signaling events mediated by HDAC Class II | ||||
| Canonical NF-kappaB pathway | |||||
| Integrin-linked kinase signaling | |||||
| Signaling events mediated by HDAC Class I | |||||
| Role of Calcineurin-dependent NFAT signaling in lymphocytes | |||||
| FoxO family signaling | |||||
| Sumoylation by RanBP2 regulates transcriptional repression | |||||
| Hedgehog signaling events mediated by Gli proteins | |||||
| Regulation of nuclear beta catenin signaling and target gene transcription | |||||
| Reactome | Separation of Sister Chromatids | ||||
| Resolution of Sister Chromatid Cohesion | |||||
| Deactivation of the beta-catenin transactivating complex | |||||
| HuR (ELAVL1) binds and stabilizes mRNA | |||||
| RHO GTPases Activate Formins | |||||
| Mitotic Prometaphase | |||||
| Cyclin A/B1 associated events during G2/M transition | |||||
| WikiPathways | Mitotic Metaphase and Anaphase | ||||
| Signaling by TGF-beta Receptor Complex | |||||
| Regulation of mRNA Stability by Proteins that Bind AU-rich Elements | |||||
| Host Interactions of HIV factors | |||||
| Influenza Life Cycle | |||||
| HIV Life Cycle | |||||
| Mitotic Prometaphase | |||||
| Mitotic G2-G2/M phases | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT02025985) Phase II Study of KPT-330 (Selinexor) in Female Patients With Advanced Gynaecologic Malignancies. U.S. National Institutes of Health. | ||||
| REF 2 | Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agents. Semin Cancer Biol. 2014 August; 0: 62-73. | ||||
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