Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05XTO
|
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| Former ID |
DIB013864
|
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| Drug Name |
ABT-100
|
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| Synonyms |
A-367074; A-409100; A-367074.1
|
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| Drug Type |
Small molecular drug
|
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| Indication | Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] | Terminated | [1] | ||
| Company |
Abbott Laboratories
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C27H19F3N4O3
|
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| Canonical SMILES |
c1([C@](COc2c(c3ccc(OC(F)(F)F)cc3)cc(C#N)cc2)(c2ccc(C#N<br />)cc2)O)n(cnc1)C.Cl
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Protein farnesyltransferase beta subunit | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Terpenoid backbone biosynthesis | ||||
| Biosynthesis of antibiotics | |||||
| NetPath Pathway | TSH Signaling Pathway | ||||
| Reactome | Inactivation, recovery and regulation of the phototransduction cascade | ||||
| WikiPathways | Visual phototransduction | ||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019239) | ||||
| REF 2 | Potent farnesyltransferase inhibitor ABT-100 abrogates acute allograft rejection. J Heart Lung Transplant. 2005 Sep;24(9):1403-9. | ||||
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