Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0Q7FC
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| Former ID |
DIB000131
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| Drug Name |
Lurtotecan
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| Synonyms |
Lurtotecan dihydrochloride; GI 147211C; GG-147211C; GG-211; GI-147211; GI-147211A; GL-147211C; GW-211
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| Drug Type |
Small molecular drug
|
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| Indication | Ovarian cancer [ICD9: 183; ICD10:C56] | Discontinued in Phase 2 | [1] | ||
| Company |
Glaxo Inc
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| Structure |
|
Download2D MOL |
|||
| Formula |
C28H30N4O6
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| Canonical SMILES |
n12c(c3c(c(c4c(n3)cc3c(c4)OCCO3)CN3CCN(CC3)C)C2)cc2c(c1<br />=O)COC(=O)[C@]2(O)CC.Cl.Cl
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Toposisomerase-1 | Target Info | Inhibitor | [2] | |
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | DNA replication | ||||
| Pathway Interaction Database | Caspase Cascade in Apoptosis | ||||
| WikiPathways | Integrated Pancreatic Cancer Pathway | ||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004939) | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2636). | ||||
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