Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03CHE
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| Former ID |
DIB000811
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| Drug Name |
PF-251802
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| Synonyms |
PF-00251802; Selective glucocorticoid receptor agonist (1), Pfizer
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| Indication | Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] | Discontinued in Phase 1 | [1] | ||
| Company |
Pfizer Inc
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
Cc1ncccc1NC(=O)c2ccc3c(CC[C@@H]4C[C@](O)(CC[C@@]34Cc5cc<br />ccc5)C(F)(F)F)c2
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| InChI |
1S/C29H29F3N2O2/c1-19-25(8-5-15-33-19)34-26(35)22-10-12-24-21(16-22)9-11-23-18-28(36,29(30,31)32)14-13-27(23,24)17-20-6-3-2-4-7-20/h2-8,10,12,15-16,23,36H,9,11,13-14,17-18H2,1H3,(H,34,35)/t23-,27+,28-/m1/s1
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| InChIKey |
QJJBNCHSWFGXML-KEKPKEOLSA-N
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| Target and Pathway | |||||
| Target(s) | Glucocorticoid receptor | Target Info | Agonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| TCR Signaling Pathway | |||||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
| Signaling events mediated by HDAC Class II | |||||
| FOXA2 and FOXA3 transcription factor networks | |||||
| Glucocorticoid receptor regulatory network | |||||
| Regulation of Androgen receptor activity | |||||
| AP-1 transcription factor network | |||||
| Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | ||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| SIDS Susceptibility Pathways | |||||
| Nuclear Receptors Meta-Pathway | |||||
| Endoderm Differentiation | |||||
| Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | |||||
| Adipogenesis | |||||
| Circadian Clock | |||||
| Nuclear Receptors | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029003) | ||||
| REF 2 | Glucocorticoids Pharmacology: Past, Present and Future. Current Pharmaceutical Design. VOLUME 16, ISSUE 32, Page(3540-3553), DOI: 10.2174/138161210793797915. | ||||
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