Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09LSY
|
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| Former ID |
DIB014513
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| Drug Name |
EDP-322
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| Synonyms |
EP-16322; Antibacterial (oral, Gram-positive infections), Enanta; EDP-MRSA-1 (oral), Enanta
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| Indication | Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] | Phase 1 | [1] | ||
| Company |
Enanta Pharmaceuticals Inc
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c1(nc(cs1)N)c1ccc(nc1)CO/N=C/1\CO[C@H]2[C@](C)(O)[C@H](<br />OC(=O)[C@](F)(C)C(=O)[C@@H]([C@H]([C@](OC1)(C[C@H](/C(=<br/>N\C(=O)CC)/[C@@H]2C)C)C)O[C@H]1[C@@H]([C@H](C[C@H](O1)C<br />)N(C)C)O)C)CC
|
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| Target and Pathway | |||||
| Target(s) | Multidrug resistance protein 1 | Target Info | Inhibitor | [2] | |
| KEGG Pathway | ABC transporters | ||||
| Bile secretion | |||||
| MicroRNAs in cancer | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| TCR Signaling Pathway | |||||
| Pathway Interaction Database | HIF-1-alpha transcription factor network | ||||
| Reactome | ABC-family proteins mediated transport | ||||
| WikiPathways | Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
| Abacavir transport and metabolism | |||||
| Multi Drug Resistance Protein 1 (Glycoprotein 1) Regulation | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Allograft Rejection | |||||
| Drug Induction of Bile Acid Pathway | |||||
| Codeine and Morphine Metabolism | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028928) | ||||
| REF 2 | In vitro activities of the novel bicyclolides modithromycin (EDP-420, EP-013420, S-013420) and EDP-322 against MDR clinical Neisseria gonorrhoeae isolates and international reference strains. J Antimicrob Chemother. 2015 Jan;70(1):173-7. | ||||
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