| Drug General Information |
| Drug ID |
D0J1GR
|
| Former ID |
DCL000359
|
| Drug Name |
CP-868596
|
| Drug Type |
Small molecular drug
|
| Indication |
Gastrointestinal cancers [ICD9: 150-159; ICD10:C15-C26]
|
Phase 3 |
[1],
[2]
|
|---|
| Therapeutic Class |
Anticancer Agents
|
| Company |
Pfizer
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C26H29N5O2
|
| InChI |
InChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3
|
| InChIKey |
DYNHJHQFHQTFTP-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
15379617, 22724199, 33999151, 78995356, 135267953, 135349234, 135626820, 136340262, 136349573, 136367704, 136920312, 137263558, 139541679, 144115852, 152258467, 160647302, 160681954, 162011433, 162038138, 162202696, 164838602, 172918813, 174006528, 174530261, 184828151, 198943954, 223366211, 223400256, 223705033, 223921696, 228815749, 247785884, 252110181, 252215199, 252451666
|
| Target and Pathway |
| Target(s) |
Alpha platelet-derived growth factor receptor |
Target Info |
Modulator |
|
|---|
|
KEGG Pathway
|
MAPK signaling pathway
|
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
Calcium signaling pathway
|
|
Cytokine-cytokine receptor interaction
|
|
Endocytosis
|
|
PI3K-Akt signaling pathway
|
|
Focal adhesion
|
|
Gap junction
|
|
Regulation of actin cytoskeleton
|
|
HTLV-I infection
|
|
Pathways in cancer
|
|
MicroRNAs in cancer
|
|
Glioma
|
|
Prostate cancer
|
|
Melanoma
|
|
Central carbon metabolism in cancer
|
|
Choline metabolism in cancer
|
|
NetPath Pathway
|
TGF_beta_Receptor Signaling Pathway
|
|
PANTHER Pathway
|
Angiogenesis
|
|
PDGF signaling pathway
|
|
Pathway Interaction Database
|
ATF-2 transcription factor network
|
|
PDGFR-alpha signaling pathway
|
|
PDGF receptor signaling network
|
|
Reactome
|
PIP3 activates AKT signaling
|
|
Constitutive Signaling by Aberrant PI3K in Cancer
|
|
RAF/MAP kinase cascade
|
|
WikiPathways
|
Regulation of Actin Cytoskeleton
|
|
Osteoblast Signaling
|
|
Focal Adhesion
|
|
Hair Follicle Development: Organogenesis (Part 2 of 3)
|
|
PIP3 activates AKT signaling
|
|
Cardiac Progenitor Differentiation
|
|
Integrated Pancreatic Cancer Pathway
|
|
Allograft Rejection
|
|
Signaling Pathways in Glioblastoma
|
|
Signaling by PDGF
|
|
Angiogenesis
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7882). |
|---|
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015430) |
|---|
