| Drug General Information |
| Drug ID |
D06GCP
|
| Former ID |
DIB002034
|
| Drug Name |
PSD-506
|
| Synonyms |
Muscarinic M2 antagonists, Roche; Ro-320-2904; M2/M3 muscarinic antagonists (benign prostate hyperplasia), Roche/Plethora; M2/M3 muscarinic antagonists (overactive bladder), Roche/Plethora; M2/M3 muscarinic antagonists (urge incontinence), Roche/Plethora; M2/M3 muscarinic antagonists (urological disorders), Roche/Plethora
|
| Indication |
Overactive bladder disorder [ICD9: 188, 596.51; ICD10:C67, N32.81]
|
Discontinued in Phase 2 |
[1]
|
|---|
| Company |
Roche Bioscience
|
| Target and Pathway |
| Target(s) |
Muscarinic acetylcholine receptor M2 |
Target Info |
Modulator |
[2]
|
|---|
| Muscarinic acetylcholine receptor M3 |
Target Info |
Modulator |
[2]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
PI3K-Akt signaling pathway
|
|
Cholinergic synapse
|
|
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
|
|
Regulation of actin cytoskeleton
|
|
Insulin secretion
|
|
Salivary secretion
|
|
Gastric acid secretion
|
|
Pancreatic secretion
|
|
PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
|
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
|
PathWhiz Pathway
|
Muscle/Heart ContractionPW000565:Gastric Acid Production
|
|
Reactome
|
Muscarinic acetylcholine receptors
|
|
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
|
Acetylcholine regulates insulin secretion
|
|
G alpha (q) signalling events
|
|
WikiPathways
|
SIDS Susceptibility Pathways
|
|
Monoamine GPCRs
|
|
Calcium Regulation in the Cardiac Cell
|
|
Regulation of Actin Cytoskeleton
|
|
GPCRs, Class A Rhodopsin-like
|
|
GPCR ligand binding
|
|
GPCR downstream signaling
|
|
GPCRs, OtherWP58:Monoamine GPCRs
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
Integration of energy metabolism
|
|
GPCRs, Other
|
| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022973) |
|---|
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. |
|---|
