Drug Information

Drug General Information
Drug ID
D00CLM
Former ID
DIB000287
Drug Name
NIP-004
Synonyms
Blood clotting modulator, Nissan; NIP-022; ONO-7746; ONO-7746); Peptidomimetic thrombopoietin agonist (thrombocytopenia), Nissan Chemical; Peptidomimetic thrombopoietin agonist (thrombocytopenia), Nissan Chemical/Ono
Indication Thrombocytopenia [ICD9: 287.3, 287.4, 287.5; ICD10:D69.6, P61.0] Phase 1 [548679]
Company
Nissan Chemical Industries Ltd
Structure
Download
2D MOL

3D MOL
Canonical SMILES
c1c(c(cc(c1)c1c(c(cs1)/C(=N/NC(=O)c1sc(cc1)C(=O)O)/C)O)<br />Cl)Cl
Target and Pathway
Target(s) Thrombopoietin Receptor Target Info Agonist [528043]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
WikiPathways Platelet Aggregation (Plug Formation)
References
Ref 548679Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027636)
Ref 528043A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis. Blood. 2006 Jun 1;107(11):4300-7. Epub 2006 Feb 16.

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