Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00IUN
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| Former ID |
DNC008203
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| Drug Name |
1-(1-(4-thiophen-3-ylphenyl)ethyl)-1H-imidazole
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C15H14N2S
|
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| Canonical SMILES |
CC(C1=CC=C(C=C1)C2=CSC=C2)N3C=CN=C3
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| InChI |
1S/C15H14N2S/c1-12(17-8-7-16-11-17)13-2-4-14(5-3-13)15-6-9-18-10-15/h2-12H,1H3
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| InChIKey |
CPEUHVZSVWFLMC-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | 17 alpha-hydroxylase-C17, 20-lyase | Target Info | Inhibitor | [1] | |
| BioCyc Pathway | Superpathway of steroid hormone biosynthesis | ||||
| Glucocorticoid biosynthesis | |||||
| Androgen biosynthesis | |||||
| KEGG Pathway | Steroid hormone biosynthesis | ||||
| Metabolic pathways | |||||
| Ovarian steroidogenesis | |||||
| Prolactin signaling pathway | |||||
| PathWhiz Pathway | Androgen and Estrogen Metabolism | ||||
| Steroidogenesis | |||||
| Reactome | Androgen biosynthesis | ||||
| Glucocorticoid biosynthesis | |||||
| Endogenous sterols | |||||
| WikiPathways | Metapathway biotransformation | ||||
| Steroid Biosynthesis | |||||
| Oxidation by Cytochrome P450 | |||||
| Metabolism of steroid hormones and vitamin D | |||||
| Glucocorticoid & Mineralcorticoid Metabolism | |||||
| Prostate Cancer | |||||
| Phase 1 - Functionalization of compounds | |||||
| References | |||||
| REF 1 | Bioorg Med Chem. 2008 Feb 15;16(4):1992-2010. Epub 2007 Nov 4.Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure. | ||||
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