Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00QHT
|
||||
| Former ID |
DIB011028
|
||||
| Drug Name |
AK-295
|
||||
| Synonyms |
Vasolex; AK-265; AK-275; AK-295; CX-295; Calpain inhibitors (neuropathy); Calpain inhibitors (neuropathy), AxoTect; Calpain inhibitors, Cortex/Alkermes
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Cerebral infarction [ICD10:I63] | Terminated | [1] | ||
| Company |
Alkermes Inc
|
||||
| Structure |
|
Download2D MOL |
|||
| Formula |
C26H40N4O6
|
||||
| Canonical SMILES |
C(=O)(C(=O)NCCCN1CCOCC1)C(NC(=O)C(NC(=O)OCc1ccccc1)CC(C<br />)C)CC
|
||||
| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Calpain | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Protein processing in endoplasmic reticulum | ||||
| Apoptosis | |||||
| Alzheimer's disease | |||||
| Reactome | Degradation of the extracellular matrix | ||||
| WikiPathways | Focal Adhesion | ||||
| Integrated Pancreatic Cancer Pathway | |||||
| Alzheimers Disease | |||||
| Integrin-mediated Cell Adhesion | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007674) | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2336). | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.