| Drug General Information |
| Drug ID |
D03GBO
|
| Former ID |
DNC012549
|
| Drug Name |
4,6-Dichloro-1H-indole-2-carboxylic acid
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C9H5Cl2NO2
|
| Canonical SMILES |
C1=C(C=C2C(=C1Cl)C=C(N2)C(=O)O)Cl
|
| InChI |
1S/C9H5Cl2NO2/c10-4-1-6(11)5-3-8(9(13)14)12-7(5)2-4/h1-3,12H,(H,13,14)
|
| InChIKey |
DHXISZKSSIWRLH-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Glutamate [NMDA] receptor subunit epsilon 1 |
Target Info |
Inhibitor |
[1]
|
|---|
| Glutamate [NMDA] receptor subunit epsilon 2 |
Target Info |
Inhibitor |
[1]
|
| NMDA receptor subunit NR1 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Ras signaling pathway
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Rap1 signaling pathway
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Calcium signaling pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Circadian entrainment
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Long-term potentiation
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Glutamatergic synapse
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Dopaminergic synapse
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Alzheimer's disease
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Amyotrophic lateral sclerosis (ALS)
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Cocaine addiction
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Amphetamine addiction
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Nicotine addiction
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Alcoholism
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Systemic lupus erythematosushsa04014:Ras signaling pathway
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Huntington's disease
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PANTHER Pathway
|
Huntington disease
|
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Ionotropic glutamate receptor pathway
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Metabotropic glutamate receptor group III pathway
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Metabotropic glutamate receptor group I pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
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Pathway Interaction Database
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Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events
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Reelin signaling pathway
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Reactome
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Unblocking of NMDA receptor, glutamate binding and activation
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CREB phosphorylation through the activation of CaMKII
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Ras activation uopn Ca2+ infux through NMDA receptor
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RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
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RAF/MAP kinase cascade
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WikiPathways
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Hypothetical Network for Drug Addiction
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
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Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
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BDNF signaling pathwayWP706:SIDS Susceptibility Pathways
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Spinal Cord Injury
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BDNF signaling pathway
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Alzheimers Disease
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| References |
| REF 1 | J Med Chem. 1990 Nov;33(11):2944-6.3-(2-carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspartate receptor complex. |
|---|
