Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03KTK
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| Former ID |
DIB013256
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| Drug Name |
TAK-937
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| Synonyms |
Cerebroprotectant (acute stroke, injection), Takeda; CB1/CB2 receptor agonist (acute stroke, injection), Takeda
|
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| Indication | Cerebrovascular ischaemia [ICD9: 434.91; ICD10:I61-I63] | Discontinued in Phase 1 | [1] | ||
| Company |
Takeda Pharmaceutical Co Ltd
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| Target and Pathway | |||||
| Target(s) | Cannabinoid receptor 2 | Target Info | Modulator | [2] | |
| Cannabinoid receptor 1 | Target Info | Modulator | [2] | ||
| KEGG Pathway | Neuroactive ligand-receptor interactionhsa04015:Rap1 signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Retrograde endocannabinoid signaling | |||||
| PANTHER Pathway | Endogenous cannabinoid signaling | ||||
| Pathway Interaction Database | N-cadherin signaling events | ||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors) | |||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Small Ligand GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like | |||||
| BDNF signaling pathway | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030875) | ||||
| REF 2 | Cerebroprotective effects of TAK-937, a cannabinoid receptor agonist, on ischemic brain damage in middle cerebral artery occluded rats and non-human primates. Brain Res. 2012 Jan 9;1430:93-100. | ||||
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