Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03SWH
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| Former ID |
DIB001834
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| Drug Name |
PNU-142633
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| Drug Type |
Small molecular drug
|
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| Indication | Migraine [ICD9: 346; ICD10:G43] | Discontinued in Phase 2 | [1] | ||
| Company |
Pharmacia & Upjohn Inc
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C24H30N4O3
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| Canonical SMILES |
N1(c2ccc(C(=O)N)cc2)CCN(CC[C@H]2c3c(cc(C(=O)NC)cc3)CCO2<br />)CC1
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| CAS Number |
CAS 187665-65-2
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 1D receptor | Target Info | Agonist | [2], [3] | |
| KEGG Pathway | cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT1 type receptor mediated signaling pathway | |||||
| Reactome | Serotonin receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013927) | ||||
| REF 2 | Further characterization of the 5-HT1 receptors mediating cardiac sympatho-inhibition in pithed rats: pharmacological correlation with the 5-HT1B and 5-HT1D subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):220-7. Epub 2003 Dec 12. | ||||
| REF 3 | Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75. | ||||
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