Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04IMY
|
||||
| Former ID |
DIB020209
|
||||
| Drug Name |
leucettine L41
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C17H13N3O3
|
||||
| InChI |
InChI=1S/C17H13N3O3/c21-16-13(8-11-6-7-14-15(9-11)23-10-22-14)19-17(20-16)18-12-4-2-1-3-5-12/h1-9H,10H2,(H2,18,19,20,21)/b13-8-
|
||||
| InChIKey |
PGPHHJBZEGSUNE-JYRVWZFOSA-N
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | Target Info | Inhibitor | [1] | |
| Cdc2-like kinase 1 | Target Info | Inhibitor | [1] | ||
| dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 | Target Info | Inhibitor | [1] | ||
| CDC-like kinase 3 | Target Info | Inhibitor | [1] | ||
| Proto-oncogene pim-1 | Target Info | Inhibitor | [1] | ||
| dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 | Target Info | Inhibitor | [2] | ||
| KEGG Pathway | Jak-STAT signaling pathway | ||||
| MicroRNAs in cancer | |||||
| Acute myeloid leukemia | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| EGFR1 Signaling Pathway | |||||
| TGF_beta_Receptor Signaling PathwayNetPath_20:IL9 Signaling Pathway | |||||
| IL5 Signaling Pathway | |||||
| IL2 Signaling Pathway | |||||
| TGF_beta_Receptor Signaling Pathway | |||||
| Pathway Interaction Database | GMCSF-mediated signaling events | ||||
| Validated targets of C-MYC transcriptional activation | |||||
| Role of Calcineurin-dependent NFAT signaling in lymphocytes | |||||
| IL5-mediated signaling events | |||||
| IL3-mediated signaling events | |||||
| C-MYB transcription factor network | |||||
| WikiPathways | mRNA ProcessingWP2858:Ectoderm Differentiation | ||||
| Hematopoietic Stem Cell Differentiation | |||||
| References | |||||
| REF 1 | Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. J Med Chem. 2011 Jun 23;54(12):4172-86. | ||||
| REF 2 | Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. J Med Chem. 2012 Nov 8;55(21):9312-30. | ||||
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