| Drug General Information |
| Drug ID |
D04JNZ
|
| Former ID |
DNC004146
|
| Drug Name |
PROSTRATIN
|
| Drug Type |
Small molecular drug
|
| Indication |
Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26]
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C22H30O6
|
| Canonical SMILES |
CC1CC2(C(C2(C)C)C3C1(C4C=C(C(=O)C4(CC(=C3)CO)O)C)O)OC(=<br />O)C
|
| InChI |
1S/C22H30O6/c1-11-6-16-20(26,18(11)25)9-14(10-23)7-15-17-19(4,5)21(17,28-13(3)24)8-12(2)22(15,16)27/h6-7,12,15-17,23,26-27H,8-10H2,1-5H3/t12-,15+,16-,17?,20-,21?,22-/m1/s1
|
| InChIKey |
BOJKFRKNLSCGHY-KKFGZBDXSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
mRNA of PKC-epsilon |
Target Info |
Inhibitor |
[1]
|
|---|
| mRNA of PKC-delta |
Target Info |
Inhibitor |
[1]
|
| Protein kinase C, delta type |
Target Info |
Inhibitor |
[1]
|
| mRNA of human PKC-eta |
Target Info |
Inhibitor |
[1]
|
| Protein kinase C gamma type |
Target Info |
Inhibitor |
[1]
|
| mRNA of Protein kinase C-theta |
Target Info |
Inhibitor |
[1]
|
| Protein kinase C, beta type |
Target Info |
Inhibitor |
[1]
|
| Protein kinase C, alpha type |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
cGMP-PKG signaling pathway
|
|
Sphingolipid signaling pathway
|
|
Vascular smooth muscle contraction
|
|
Tight junction
|
|
Fc epsilon RI signaling pathway
|
|
Fc gamma R-mediated phagocytosis
|
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Inflammatory mediator regulation of TRP channels
|
|
Type II diabetes mellitus
|
|
MicroRNAs in cancerhsa04062:Chemokine signaling pathway
|
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Neurotrophin signaling pathway
|
|
GnRH signaling pathway
|
|
Estrogen signaling pathway
|
|
Type II diabetes mellitushsa04062:Chemokine signaling pathway
|
|
Type II diabetes mellitushsa04270:Vascular smooth muscle contraction
|
|
Inflammatory mediator regulation of TRP channelshsa04010:MAPK signaling pathway
|
|
ErbB signaling pathway
|
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
Calcium signaling pathway
|
|
HIF-1 signaling pathway
|
|
Phosphatidylinositol signaling system
|
|
mTOR signaling pathway
|
|
Wnt signaling pathway
|
|
VEGF signaling pathway
|
|
Focal adhesion
|
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Gap junction
|
|
Natural killer cell mediated cytotoxicity
|
|
Leukocyte transendothelial migration
|
|
Circadian entrainment
|
|
Long-term potentiation
|
|
Retrograde endocannabinoid signaling
|
|
Glutamatergic synapse
|
|
Cholinergic synapse
|
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Serotonergic synapse
|
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GABAergic synapse
|
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Dopaminergic synapse
|
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Long-term depression
|
|
Insulin secretion
|
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Melanogenesis
|
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Thyroid hormone synthesis
|
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Thyroid hormone signaling pathway
|
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Oxytocin signaling pathway
|
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Aldosterone-regulated sodium reabsorption
|
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Endocrine and other factor-regulated calcium reabsorption
|
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Salivary secretion
|
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Gastric acid secretion
|
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Pancreatic secretion
|
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Amphetamine addiction
|
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Morphine addiction
|
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Vibrio cholerae infection
|
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African trypanosomiasis
|
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Amoebiasis
|
|
Hepatitis B
|
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Pathways in cancer
|
|
Proteoglycans in cancer
|
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MicroRNAs in cancer
|
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Glioma
|
|
Non-small cell lung cancer
|
|
Choline metabolism in cancerhsa04064:NF-kappa B signaling pathway
|
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T cell receptor signaling pathway
|
|
Adipocytokine signaling pathway
|
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Measleshsa04010:MAPK signaling pathway
|
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Chemokine signaling pathway
|
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NF-kappa B signaling pathway
|
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B cell receptor signaling pathway
|
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Carbohydrate digestion and absorption
|
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Leishmaniasis
|
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Influenza A
|
|
Choline metabolism in cancerhsa04010:MAPK signaling pathway
|
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PI3K-Akt signaling pathway
|
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Adrenergic signaling in cardiomyocytes
|
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Pathogenic Escherichia coli infection
|
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Choline metabolism in cancer
|
|
NetPath Pathway
|
IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
|
|
PANTHER Pathway
|
Alpha adrenergic receptor signaling pathway
|
|
Alzheimer disease-amyloid secretase pathway
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Angiogenesis
|
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Apoptosis signaling pathway
|
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EGF receptor signaling pathway
|
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Endothelin signaling pathway
|
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FGF signaling pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Inflammation mediated by chemokine and cytokine signaling pathway
|
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
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VEGF signaling pathway
|
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Wnt signaling pathway
|
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5HT2 type receptor mediated signaling pathway
|
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Histamine H1 receptor mediated signaling pathway
|
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Oxytocin receptor mediated signaling pathway
|
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Thyrotropin-releasing hormone receptor signaling pathway
|
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CCKR signaling map STP00002:Alpha adrenergic receptor signaling pathway
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B cell activation
|
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CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
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Thyrotropin-releasing hormone receptor signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
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T cell activation
|
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Metabotropic glutamate receptor group I pathway
|
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PDGF signaling pathway
|
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Angiotensin II-stimulated signaling through G proteins and beta-arrestin
|
|
CCKR signaling map ST
|
|
Pathway Interaction Database
|
Endothelins
|
|
LPA receptor mediated events
|
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TCR signaling in naï
|
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LPA4-mediated signaling events
|
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CDC42 signaling events
|
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TCR signaling in naï
|
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Thromboxane A2 receptor signaling
|
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
|
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IL2-mediated signaling events
|
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PDGFR-beta signaling pathway
|
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IL8- and CXCR1-mediated signaling events
|
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Regulation of Ras family activation
|
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Downstream signaling in naï
|
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Endothelins
|
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IGF1 pathway
|
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Ceramide signaling pathway
|
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IFN-gamma pathway
|
|
ErbB1 downstream signaling
|
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Syndecan-4-mediated signaling events
|
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IL6-mediated signaling events
|
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Hedgehog signaling events mediated by Gli proteins
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
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PAR1-mediated thrombin signaling events
|
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Syndecan-2-mediated signaling events
|
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Validated transcriptional targets of TAp63 isoforms
|
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p53 pathway
|
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Trk receptor signaling mediated by the MAPK pathway
|
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Trk receptor signaling mediated by PI3K and PLC-gamma
|
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Alpha-synuclein signalingendothelinpathway:Endothelins
|
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Role of Calcineurin-dependent NFAT signaling in lymphocytesendothelinpathway:Endothelins
|
|
Retinoic acid receptors-mediated signaling
|
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IL8- and CXCR2-mediated signaling events
|
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IL8- and CXCR1-mediated signaling eventsendothelinpathway:Endothelins
|
|
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
|
|
Fc-epsilon receptor I signaling in mast cells
|
|
Ras signaling in the CD4+ TCR pathway
|
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JNK signaling in the CD4+ TCR pathway
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Canonical NF-kappaB pathway
|
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Signaling events regulated by Ret tyrosine kinase
|
|
mTOR signaling pathway
|
|
ATF-2 transcription factor network
|
|
VEGFR1 specific signals
|
|
a6b1 and a6b4 Integrin signaling
|
|
PathWhiz Pathway
|
Fc Epsilon Receptor I Signaling in Mast Cells
|
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Activation of PKC through G protein coupled receptor
|
|
Reactome
|
Effects of PIP2 hydrolysis
|
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DAG and IP3 signaling
|
|
Role of phospholipids in phagocytosis
|
|
G alpha (z) signalling eventsR-HSA-111465:Apoptotic cleavage of cellular proteins
|
|
Calmodulin induced events
|
|
G alpha (z) signalling events
|
|
HuR (ELAVL1) binds and stabilizes mRNA
|
|
VEGFR2 mediated cell proliferation
|
|
CLEC7A (Dectin-1) signaling
|
|
Interferon gamma signalingR-HSA-111465:Apoptotic cleavage of cellular proteins
|
|
Interferon gamma signalingR-HSA-114508:Effects of PIP2 hydrolysis
|
|
G alpha (z) signalling eventsR-HSA-111933:Calmodulin induced events
|
|
Disinhibition of SNARE formation
|
|
Trafficking of GluR2-containing AMPA receptors
|
|
WNT5A-dependent internalization of FZD4
|
|
Response to elevated platelet cytosolic Ca2+R-HSA-111465:Apoptotic cleavage of cellular proteins
|
|
Inactivation, recovery and regulation of the phototransduction cascade
|
|
FCERI mediated NF-kB activation
|
|
G alpha (z) signalling eventsR-HSA-114516:Disinhibition of SNARE formation
|
|
Activation of NF-kappaB in B cells
|
|
Depolymerisation of the Nuclear Lamina
|
|
Response to elevated platelet cytosolic Ca2+R-HSA-111933:Calmodulin induced events
|
|
Regulation of KIT signaling
|
|
EGFR Transactivation by Gastrin
|
|
Syndecan interactions
|
|
Acetylcholine regulates insulin secretion
|
|
Ca2+ pathway
|
|
Response to elevated platelet cytosolic Ca2+
|
|
WikiPathways
|
Hypothetical Network for Drug Addiction
|
|
Calcium Regulation in the Cardiac Cell
|
|
Wnt Signaling Pathway
|
|
Wnt Signaling Pathway and Pluripotency
|
|
G Protein Signaling Pathways
|
|
Myometrial Relaxation and Contraction Pathways
|
|
Oncostatin M Signaling Pathway
|
|
miRs in Muscle Cell Differentiation
|
|
GPCR downstream signaling
|
|
Effects of PIP2 hydrolysis
|
|
Physiological and Pathological Hypertrophy of the HeartWP69:TCR Signaling Pathway
|
|
Type II interferon signaling (IFNG)
|
|
Insulin Signaling
|
|
EGF/EGFR Signaling Pathway
|
|
MAPK Signaling Pathway
|
|
IL-6 signaling pathway
|
|
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
|
|
DAG and IP3 signaling
|
|
Alpha 6 Beta 4 signaling pathway
|
|
BDNF signaling pathway
|
|
Corticotropin-releasing hormone
|
|
AGE/RAGE pathway
|
|
B Cell Receptor Signaling Pathway
|
|
Signaling Pathways in Glioblastoma
|
|
Opioid Signalling
|
|
Apoptotic execution phase
|
|
Type II diabetes mellitusWP69:TCR Signaling Pathway
|
|
Type II diabetes mellitusWP536:Calcium Regulation in the Cardiac Cell
|
|
Effects of PIP2 hydrolysisWP536:Calcium Regulation in the Cardiac Cell
|
|
Wnt Signaling Pathway Netpath
|
|
Response to elevated platelet cytosolic Ca2+WP69:TCR Signaling Pathway
|
|
Fc epsilon receptor (FCERI) signaling
|
|
TCR signaling
|
|
Netrin-1 signaling
|
|
Apoptotic execution phaseWP536:Calcium Regulation in the Cardiac Cell
|
|
Kit receptor signaling pathway
|
|
Signaling by the B Cell Receptor (BCR)
|
|
Response to elevated platelet cytosolic Ca2+
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
|
Physiological and Pathological Hypertrophy of the HeartWP673:ErbB Signaling Pathway
|
|
Transcriptional activation by NRF2
|
|
Human Complement System
|
|
Cardiac Hypertrophic Response
|
|
Syndecan interactions
|
|
Signaling by SCF-KIT
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
T-Cell Receptor and Co-stimulatory Signaling
|
|
Spinal Cord Injury
|
|
Integrated Pancreatic Cancer Pathway
|
|
Pathogenic Escherichia coli infection
|
|
Endothelin Pathways
|
|
Regulation of Microtubule Cytoskeleton
|
|
FSH signaling pathway
|
|
Integration of energy metabolism
|
|
TOR Signaling
|
| References |
| REF 1 | J Med Chem. 1992 May 29;35(11):1978-86.A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. |
|---|
