| Drug General Information |
| Drug ID |
D04QRS
|
| Former ID |
DNC011654
|
| Drug Name |
PNU-22394
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C13H16N2
|
| Canonical SMILES |
CN1C2=C(CCNCC2)C3=CC=CC=C31
|
| InChI |
1S/C13H16N2/c1-15-12-5-3-2-4-10(12)11-6-8-14-9-7-13(11)15/h2-5,14H,6-9H2,1H3
|
| InChIKey |
ZBXDOQWPGBISAR-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Amine oxidase [flavin-containing] B |
Target Info |
Inhibitor |
[1]
|
|---|
| Amine oxidase [flavin-containing] A |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Superpathway of tryptophan utilization
|
|
Tryptophan degradation via tryptamine
|
|
Dopamine degradation
|
|
Putrescine degradation III
|
|
Noradrenaline and adrenaline degradationPWY66-401:Superpathway of tryptophan utilization
|
|
Noradrenaline and adrenaline degradation
|
|
Serotonin degradation
|
|
Superpathway of melatonin degradation
|
|
Melatonin degradation II
|
|
KEGG Pathway
|
Glycine, serine and threonine metabolism
|
|
Arginine and proline metabolism
|
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Histidine metabolism
|
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Tyrosine metabolism
|
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Phenylalanine metabolism
|
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Tryptophan metabolism
|
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Drug metabolism - cytochrome P450
|
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Metabolic pathways
|
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Serotonergic synapse
|
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Dopaminergic synapse
|
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Cocaine addiction
|
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Amphetamine addiction
|
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Alcoholismhsa00260:Glycine, serine and threonine metabolism
|
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Alcoholism
|
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NetPath Pathway
|
IL4 Signaling Pathway
|
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PANTHER Pathway
|
Adrenaline and noradrenaline biosynthesis
|
|
5-Hydroxytryptamine degredation
|
|
Dopamine receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
|
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Dopamine receptor mediated signaling pathway
|
|
Pathway Interaction Database
|
Alpha-synuclein signaling
|
|
PathWhiz Pathway
|
Histidine Metabolism
|
|
Tyrosine Metabolism
|
|
Glycine and Serine Metabolism
|
|
Reactome
|
Norepinephrine Neurotransmitter Release Cycle
|
|
WikiPathways
|
Tryptophan metabolism
|
|
Dopamine metabolism
|
|
Phase 1 - Functionalization of compoundsWP706:SIDS Susceptibility Pathways
|
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Biogenic Amine Synthesis
|
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Oxidative Stress
|
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Phase 1 - Functionalization of compounds
|
|
Neurotransmitter Release Cycle
|
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Neurotransmitter Clearance In The Synaptic Cleft
|
|
Serotonin Transporter Activity
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. |
|---|
