| Drug General Information |
| Drug ID |
D06QBJ
|
| Former ID |
DIB020679
|
| Drug Name |
PF-3644022
|
| Synonyms |
PF3644022; PF 3644022
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
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| Structure |
|
Download
2D MOL
|
| Formula |
C21H18N4OS
|
| InChI |
InChI=1S/C21H18N4OS/c1-11-3-4-13(10-22-11)15-6-5-14-16(25-15)7-8-17-18(14)19-20(27-17)21(26)24-12(2)9-23-19/h3-8,10,12,23H,9H2,1-2H3,(H,24,26)/t12-/m1/s1
|
| InChIKey |
CMWRPDHVGMHLSZ-GFCCVEGCSA-N
|
| PubChem Compound ID |
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| PubChem Substance ID |
|
| Target and Pathway |
| Target(s) |
MAPKAP kinase 2 |
Target Info |
Inhibitor |
[1]
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|
KEGG Pathway
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MAPK signaling pathway
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VEGF signaling pathway
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Neurotrophin signaling pathway
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Viral carcinogenesis
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NetPath Pathway
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IL2 Signaling Pathway
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PANTHER Pathway
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Angiogenesis
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Interleukin signaling pathway
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PDGF signaling pathway
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VEGF signaling pathway
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Ras Pathway
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p38 MAPK pathway
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Pathway Interaction Database
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IL2-mediated signaling events
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p38 signaling mediated by MAPKAP kinases
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Signaling mediated by p38-alpha and p38-beta
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Signaling events mediated by VEGFR1 and VEGFR2
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Trk receptor signaling mediated by the MAPK pathway
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Reactome
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p38MAPK events
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Oxidative Stress Induced Senescence
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Regulation of HSF1-mediated heat shock response
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VEGFA-VEGFR2 Pathway
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activated TAK1 mediates p38 MAPK activation
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WikiPathways
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Serotonin Receptor 4/6/7 and NR3C Signaling
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
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Serotonin HTR1 Group and FOS Pathway
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p38 MAPK Signaling Pathway
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MAPK Signaling Pathway
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FAS pathway and Stress induction of HSP regulation
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MAP kinase activation in TLR cascade
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Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
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Arachidonic acid metabolism
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Structural Pathway of Interleukin 1 (IL-1)
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Regulation of Microtubule Cytoskeleton
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IL-1 signaling pathway
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NGF signalling via TRKA from the plasma membrane
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MAPK targets/ Nuclear events mediated by MAP kinases
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| References |
| REF 1 | A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. J Pharmacol Exp Ther. 2010 Jun;333(3):797-807. |
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