| Drug General Information |
| Drug ID |
D07OJZ
|
| Former ID |
DNCL003627
|
| Drug Name |
INCB28060
|
| Drug Type |
Small molecular drug
|
| Indication |
Hepatocellular carcinoma [ICD9: 155; ICD10:C22.0]
|
Phase 2 |
[1]
|
|---|
| Company |
Incyte
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C23H17FN6O
|
| InChI |
InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
|
| InChIKey |
LIOLIMKSCNQPLV-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
56473134, 81021450, 140970141, 144116075, 152159599, 162011567, 162205174, 163643087, 163763208, 165246955, 174006562, 174525845, 185990469, 189622871, 198989884, 210274845, 210280477, 223382041, 223705042, 224332520, 227639025, 242591280, 244011878, 249565587, 249803978, 252110125, 252215585, 252442769, 252451689
|
| Target and Pathway |
| Target(s) |
Hepatocyte growth factor receptor |
Target Info |
Modulator |
[2]
|
|---|
|
KEGG Pathway
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
Cytokine-cytokine receptor interaction
|
|
Endocytosis
|
|
PI3K-Akt signaling pathway
|
|
Axon guidance
|
|
Focal adhesion
|
|
Adherens junction
|
|
Bacterial invasion of epithelial cells
|
|
Epithelial cell signaling in Helicobacter pylori infection
|
|
Malaria
|
|
Pathways in cancer
|
|
Transcriptional misregulation in cancer
|
|
Proteoglycans in cancer
|
|
MicroRNAs in cancer
|
|
Renal cell carcinoma
|
|
Melanoma
|
|
Central carbon metabolism in cancer
|
|
Pathway Interaction Database
|
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
|
|
Arf6 signaling events
|
|
Signaling events mediated by TCPTP
|
|
Posttranslational regulation of adherens junction stability and dissassembly
|
|
Direct p53 effectors
|
|
Syndecan-1-mediated signaling events
|
|
Stabilization and expansion of the E-cadherin adherens junction
|
|
a6b1 and a6b4 Integrin signaling
|
|
FGF signaling pathway
|
|
Regulation of retinoblastoma protein
|
|
Reactome
|
Sema4D mediated inhibition of cell attachment and migration
|
|
WikiPathways
|
TGF beta Signaling Pathway
|
|
Signaling of Hepatocyte Growth Factor Receptor
|
|
Focal Adhesion
|
|
Extracellular vesicle-mediated signaling in recipient cells
|
|
Signaling Pathways in Glioblastoma
|
|
miR-targeted genes in squamous cell - TarBase
|
|
miR-targeted genes in muscle cell - TarBase
|
|
miR-targeted genes in lymphocytes - TarBase
|
|
miR-targeted genes in epithelium - TarBase
|
|
Semaphorin interactions
|
| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031741) |
|---|
| REF 2 | National Cancer Institute Drug Dictionary (drug id 666907). |
|---|
