| Drug General Information |
| Drug ID |
D07WSB
|
| Former ID |
DNC010775
|
| Drug Name |
N-(4-amino-3'-methylbiphenyl-3-yl)benzamide
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C20H18N2O
|
| Canonical SMILES |
CC1=CC=CC(=C1)C2=CC(=C(C=C2)N)NC(=O)C3=CC=CC=C3
|
| InChI |
1S/C20H18N2O/c1-14-6-5-9-16(12-14)17-10-11-18(21)19(13-17)22-20(23)15-7-3-2-4-8-15/h2-13H,21H2,1H3,(H,22,23)
|
| InChIKey |
VPXVDXWJQKJAAI-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Histone deacetylase 2 |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
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Cell cycle
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Notch signaling pathway
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Thyroid hormone signaling pathway
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Huntington's disease
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Alcoholism
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Epstein-Barr virus infection
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Pathways in cancer
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Transcriptional misregulation in cancer
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Viral carcinogenesis
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Chronic myeloid leukemia
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Wnt signaling pathway
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Pathway Interaction Database
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Regulation of nuclear SMAD2/3 signaling
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Signaling events mediated by HDAC Class I
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Regulation of Telomerase
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Glucocorticoid receptor regulatory network
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Direct p53 effectors
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Hedgehog signaling events mediated by Gli proteins
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Regulation of nuclear beta catenin signaling and target gene transcription
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Reactome
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p75NTR negatively regulates cell cycle via SC1
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NOTCH1 Intracellular Domain Regulates Transcription
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Constitutive Signaling by NOTCH1 PEST Domain Mutants
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Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
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HDACs deacetylate histones
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NoRC negatively regulates rRNA expression
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RNA Polymerase I Transcription Initiation
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Factors involved in megakaryocyte development and platelet production
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WikiPathways
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Notch Signaling Pathway
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Notch Signaling Pathway
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Neural Crest Differentiation
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Signalling by NGF
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RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
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Factors involved in megakaryocyte development and platelet production
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Cell Cycle
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| References |
| REF 1 | Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. Epub 2010 Mar 30.Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. |
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