| Drug General Information |
| Drug ID |
D08FOC
|
| Former ID |
DNC001081
|
| Drug Name |
Oxotremorine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C12H18N2O
|
| InChI |
InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2
|
| InChIKey |
RSDOPYMFZBJHRL-UHFFFAOYSA-N
|
| CAS Number |
CAS 17360-35-9
|
| PubChem Compound ID |
|
| PubChem Substance ID |
9688, 459069, 3135307, 5204099, 7979247, 8152842, 11111578, 11113735, 11335585, 11360824, 11364342, 11364805, 11366904, 11367367, 11369466, 11369929, 11372797, 11374542, 11377628, 11378096, 11461796, 11485212, 11489384, 11491414, 11492727, 11495262, 11495689, 15121093, 26732553, 26751921, 29223719, 47365120, 47662212, 47810683, 47885342, 48334423, 50039957, 50104597, 50237746, 53786784, 57322362, 85209959, 85787108, 90341593, 92308793, 103088501, 103156731, 103165591, 103918252, 104306964
|
| Target and Pathway |
| Target(s) |
Muscarinic acetylcholine receptor M2 |
Target Info |
Agonist |
[2]
|
|---|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
PI3K-Akt signaling pathway
|
|
Cholinergic synapse
|
|
Regulation of actin cytoskeleton
|
|
PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
|
|
PathWhiz Pathway
|
Muscle/Heart Contraction
|
|
Reactome
|
Muscarinic acetylcholine receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
SIDS Susceptibility Pathways
|
|
Monoamine GPCRs
|
|
Calcium Regulation in the Cardiac Cell
|
|
Regulation of Actin Cytoskeleton
|
|
GPCRs, Class A Rhodopsin-like
|
|
GPCR ligand binding
|
|
GPCR downstream signaling
|
|
GPCRs, Other
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 302). |
|---|
| REF 2 | Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice. Mol Pharmacol. 2002 Nov;62(5):1084-93. |
|---|
