| Drug General Information |
| Drug ID |
D08IDC
|
| Former ID |
DNC008618
|
| Drug Name |
3-methoxy-5-(6-methoxynaphthalen-2-yl)pyridine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C17H15NO2
|
| Canonical SMILES |
COC1=CC2=C(C=C1)C=C(C=C2)C3=CC(=CN=C3)OC
|
| InChI |
1S/C17H15NO2/c1-19-16-6-5-12-7-13(3-4-14(12)8-16)15-9-17(20-2)11-18-10-15/h3-11H,1-2H3
|
| InChIKey |
SEXSHORPOJSDHK-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Cytochrome P450 11B1, mitochondrial |
Target Info |
Inhibitor |
[1]
|
|---|
| Cytochrome P450 3A4 |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Superpathway of steroid hormone biosynthesis
|
|
Glucocorticoid biosynthesis
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Mineralocorticoid biosynthesis
|
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KEGG Pathway
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Steroid hormone biosynthesis
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Metabolic pathwayshsa00140:Steroid hormone biosynthesis
|
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Linoleic acid metabolism
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Retinol metabolism
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Metabolism of xenobiotics by cytochrome P450
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Drug metabolism - cytochrome P450
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Drug metabolism - other enzymes
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Metabolic pathways
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Bile secretion
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Chemical carcinogenesis
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PathWhiz Pathway
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SteroidogenesisPW000015:Caffeine Metabolism
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Retinol Metabolism
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Reactome
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Glucocorticoid biosynthesis
|
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Endogenous sterolsR-HSA-211981:Xenobiotics
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Aflatoxin activation and detoxification
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WikiPathways
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Metapathway biotransformation
|
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Oxidation by Cytochrome P450
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Metabolism of steroid hormones and vitamin D
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Corticotropin-releasing hormoneWP702:Metapathway biotransformation
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Aflatoxin B1 metabolism
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Estrogen metabolism
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Benzo(a)pyrene metabolism
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Tamoxifen metabolism
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Tryptophan metabolism
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Nuclear Receptors in Lipid Metabolism and Toxicity
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Nuclear Receptors Meta-Pathway
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Farnesoid X Receptor Pathway
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Vitamin D Receptor Pathway
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Felbamate Metabolism
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Lidocaine metabolism
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Nifedipine Activity
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Colchicine Metabolic Pathway
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Irinotecan Pathway
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Drug Induction of Bile Acid Pathway
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Fatty Acid Omega Oxidation
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Codeine and Morphine Metabolism
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| References |
| REF 1 | J Med Chem. 2008 Aug 28;51(16):5064-74. Epub 2008 Aug 1.Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization onpotency and selectivity. |
|---|
