| Drug General Information |
| Drug ID |
D08PET
|
| Former ID |
DIB007362
|
| Drug Name |
P70S6 kinase inhibitors
|
| Synonyms |
P70S6 kinase inhibitors (cancer/tuberous sclerosis); P70S6 kinase inhibitors (cancer/tuberous sclerosis), Vertex
|
| Indication |
Cancer [ICD9: 140-229; ICD10:C00-C96]
|
Investigative |
[1]
|
|---|
| Company |
Vertex Pharmaceuticals Inc
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Canonical SMILES |
c1(ccc2c(c1)nc(n2C1CCC1)c1nonc1N)N
|
| Target and Pathway |
| Target(s) |
Ribosomal protein S6 kinase |
Target Info |
Inhibitor |
[2]
|
|---|
|
KEGG Pathway
|
ErbB signaling pathway
|
|
HIF-1 signaling pathway
|
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mTOR signaling pathway
|
|
PI3K-Akt signaling pathway
|
|
AMPK signaling pathway
|
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TGF-beta signaling pathway
|
|
Fc gamma R-mediated phagocytosis
|
|
Insulin signaling pathway
|
|
Proteoglycans in cancer
|
|
Acute myeloid leukemia
|
|
Choline metabolism in cancer
|
|
PANTHER Pathway
|
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
|
|
PDGF signaling pathway
|
|
PI3 kinase pathway
|
|
p53 pathway by glucose deprivation
|
|
CCKR signaling map ST
|
|
Pathway Interaction Database
|
Insulin Pathway
|
|
IL4-mediated signaling events
|
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CDC42 signaling events
|
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Angiopoietin receptor Tie2-mediated signaling
|
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Regulation of Telomerase
|
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mTOR signaling pathway
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IGF1 pathway
|
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IL2 signaling events mediated by PI3K
|
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Integrins in angiogenesis
|
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RXR and RAR heterodimerization with other nuclear receptor
|
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Signaling events mediated by Stem cell factor receptor (c-Kit)
|
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a6b1 and a6b4 Integrin signaling
|
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TGF-beta receptor signaling
|
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PathWhiz Pathway
|
Leucine Stimulation on Insulin Signaling
|
|
Reactome
|
mTORC1-mediated signalling
|
|
WikiPathways
|
ErbB Signaling Pathway
|
|
Interferon type I signaling pathways
|
|
G13 Signaling Pathway
|
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IL-2 Signaling Pathway
|
|
Insulin Signaling
|
|
Cytoplasmic Ribosomal Proteins
|
|
EGF/EGFR Signaling Pathway
|
|
IL-4 Signaling Pathway
|
|
IL-6 signaling pathway
|
|
Kit receptor signaling pathway
|
|
Apoptosis-related network due to altered Notch3 in ovarian cancer
|
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Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
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BDNF signaling pathway
|
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Interleukin-11 Signaling Pathway
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FSH signaling pathway
|
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Leptin signaling pathway
|
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TSH signaling pathway
|
|
Signaling by Insulin receptor
|
|
TOR Signaling
|
|
AMPK Signaling
|
|
IL-5 Signaling Pathway
|
| References |
| REF 1 | 4-(Benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: potent and selective p70S6 kinase inhibitors. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5191-4 |
|---|
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1525). |
|---|
