| Drug General Information |
| Drug ID |
D09DRF
|
| Former ID |
DNC002855
|
| Drug Name |
3-(Benzyloxy)Pyridin-2-Amine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C12H12N2O
|
| Canonical SMILES |
C1=CC=C(C=C1)COC2=C(N=CC=C2)N
|
| InChI |
1S/C12H12N2O/c13-12-11(7-4-8-14-12)15-9-10-5-2-1-3-6-10/h1-8H,9H2,(H2,13,14)
|
| InChIKey |
NMCBWICNRJLKKM-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
147687, 854545, 3136310, 5374531, 7885282, 10224218, 11380072, 11536854, 14794272, 24848659, 44421380, 46393467, 46508486, 46513745, 47365867, 49831945, 60941616, 77016222, 84981869, 87560008, 87619622, 90271459, 92254272, 92714347, 97301785, 103124235, 103465592, 104401787, 117529532, 117529533, 117535806, 118050048, 118274826, 124437151, 124595268, 125345776, 126576430, 126588371, 126624209, 126655470, 126667270, 126734493, 128722141, 135045671, 135699490, 135716236, 136912640, 136991701, 137029888, 140054210
|
| Target and Pathway |
| Target(s) |
Mitogen-activated protein kinase 14 |
Target Info |
Inhibitor |
[1]
|
|---|
| Leukotriene A-4 hydrolase |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Leukotriene biosynthesis
|
|
KEGG Pathway
|
MAPK signaling pathway
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Rap1 signaling pathway
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FoxO signaling pathway
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Sphingolipid signaling pathway
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Adrenergic signaling in cardiomyocytes
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VEGF signaling pathway
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Osteoclast differentiation
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Signaling pathways regulating pluripotency of stem cells
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Platelet activation
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Toll-like receptor signaling pathway
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NOD-like receptor signaling pathway
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RIG-I-like receptor signaling pathway
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T cell receptor signaling pathway
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Fc epsilon RI signaling pathway
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TNF signaling pathway
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Leukocyte transendothelial migration
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Neurotrophin signaling pathway
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Retrograde endocannabinoid signaling
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Dopaminergic synapse
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Inflammatory mediator regulation of TRP channels
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GnRH signaling pathway
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Progesterone-mediated oocyte maturation
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Prolactin signaling pathway
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Amyotrophic lateral sclerosis (ALS)
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Epithelial cell signaling in Helicobacter pylori infection
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Shigellosis
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Salmonella infection
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Pertussis
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Leishmaniasis
|
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Chagas disease (American trypanosomiasis)
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Toxoplasmosis
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Tuberculosis
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Hepatitis C
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Influenza A
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Epstein-Barr virus infection
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Proteoglycans in cancerhsa00590:Arachidonic acid metabolism
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Metabolic pathways
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|
NetPath Pathway
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IL5 Signaling Pathway
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FSH Signaling Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Alzheimer disease-amyloid secretase pathway
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Angiogenesis
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B cell activation
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EGF receptor signaling pathway
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FGF signaling pathway
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Interferon-gamma signaling pathway
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Oxidative stress response
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Parkinson disease
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TGF-beta signaling pathway
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Toll receptor signaling pathway
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VEGF signaling pathway
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Ras Pathway
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p53 pathway feedback loops 2
|
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p38 MAPK pathway
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CCKR signaling map ST
|
|
Pathway Interaction Database
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Endothelins
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BCR signaling pathway
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p73 transcription factor network
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p38 MAPK signaling pathway
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Atypical NF-kappaB pathway
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IL4-mediated signaling events
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CD40/CD40L signaling
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IL12-mediated signaling events
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Regulation of p38-alpha and p38-beta
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CDC42 signaling events
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Angiopoietin receptor Tie2-mediated signaling
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FAS (CD95) signaling pathway
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Thromboxane A2 receptor signaling
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Glucocorticoid receptor regulatory network
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IL2-mediated signaling events
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Rapid glucocorticoid signaling
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Regulation of Androgen receptor activity
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ATF-2 transcription factor network
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IL6-mediated signaling events
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p38 signaling mediated by MAPKAP kinases
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Retinoic acid receptors-mediated signaling
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CXCR3-mediated signaling events
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Signaling mediated by p38-alpha and p38-beta
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EPO signaling pathway
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Signaling events mediated by VEGFR1 and VEGFR2
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p53 pathway
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S1P2 pathway
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Trk receptor signaling mediated by the MAPK pathway
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VEGFR3 signaling in lymphatic endothelium
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FGF signaling pathway
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RAC1 signaling pathway
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Regulation of retinoblastoma protein
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PathWhiz Pathway
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Fc Epsilon Receptor I Signaling in Mast CellsPW000044:Arachidonic Acid Metabolism
|
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Reactome
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NOD1/2 Signaling Pathway
|
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p38MAPK events
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ERK/MAPK targets
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Activation of PPARGC1A (PGC-1alpha) by phosphorylation
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Oxidative Stress Induced Senescence
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CDO in myogenesis
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DSCAM interactions
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ADP signalling through P2Y purinoceptor 1
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Platelet sensitization by LDL
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VEGFA-VEGFR2 Pathway
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activated TAK1 mediates p38 MAPK activation
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Activation of the AP-1 family of transcription factors
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KSRP (KHSRP) binds and destabilizes mRNA
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WikiPathways
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Toll-like receptor signaling pathway
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Monoamine Transport
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Serotonin HTR1 Group and FOS Pathway
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TCR Signaling Pathway
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Senescence and Autophagy in Cancer
|
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Interferon type I signaling pathways
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Insulin Signaling
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EGF/EGFR Signaling Pathway
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MAPK Cascade
|
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Oxidative Stress
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p38 MAPK Signaling Pathway
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IL-4 Signaling Pathway
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MAPK Signaling Pathway
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TGF beta Signaling Pathway
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Kit receptor signaling pathway
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Cardiac Hypertrophic Response
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MAP kinase activation in TLR cascade
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Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
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Nanoparticle-mediated activation of receptor signaling
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Structural Pathway of Interleukin 1 (IL-1)
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JAK/STAT
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Amyotrophic lateral sclerosis (ALS)
|
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Alpha 6 Beta 4 signaling pathway
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Cardiac Progenitor Differentiation
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BDNF signaling pathway
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Integrated Pancreatic Cancer Pathway
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Oncostatin M Signaling Pathway
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Parkinsons Disease Pathway
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Corticotropin-releasing hormone
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AGE/RAGE pathway
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B Cell Receptor Signaling Pathway
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Prostate Cancer
|
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TSLP Signaling Pathway
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TWEAK Signaling Pathway
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FSH signaling pathway
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Leptin signaling pathway
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RANKL/RANK Signaling Pathway
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miR-targeted genes in muscle cell - TarBase
|
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miR-targeted genes in lymphocytes - TarBase
|
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miR-targeted genes in leukocytes - TarBase
|
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miR-targeted genes in epithelium - TarBase
|
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IL-1 signaling pathway
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Signal amplification
|
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Platelet homeostasis
|
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NGF signalling via TRKA from the plasma membrane
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Myogenesis
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DSCAM interactions
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MicroRNAs in cardiomyocyte hypertrophy
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Angiogenesis
|
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Physiological and Pathological Hypertrophy of the Heart
|
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Regulation of toll-like receptor signaling pathwayWP2650:Arachidonic acid metabolism
|
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Eicosanoid Synthesis
|
| References |
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |
|---|
