| Drug General Information |
| Drug ID |
D09LZA
|
| Former ID |
DNCL003440
|
| Drug Name |
CS-4771
|
| Indication |
Sepsis [ICD9: 995.91; ICD10:A40, A41]
|
Discontinued in Phase 1 |
[1]
|
|---|
| Company |
Daiichi Sankyo
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Target and Pathway |
| Target(s) |
Toll-like receptor 4 |
Target Info |
Modulator |
[2]
|
|---|
|
KEGG Pathway
|
NF-kappa B signaling pathway
|
|
HIF-1 signaling pathway
|
|
Phagosome
|
|
PI3K-Akt signaling pathway
|
|
Toll-like receptor signaling pathway
|
|
Pathogenic Escherichia coli infection
|
|
Salmonella infection
|
|
Pertussis
|
|
Legionellosis
|
|
Leishmaniasis
|
|
Chagas disease (American trypanosomiasis)
|
|
Malaria
|
|
Toxoplasmosis
|
|
Amoebiasis
|
|
Tuberculosis
|
|
Hepatitis B
|
|
Measles
|
|
Influenza A
|
|
Proteoglycans in cancer
|
|
Inflammatory bowel disease (IBD)
|
|
Rheumatoid arthritis
|
|
NetPath Pathway
|
IL5 Signaling Pathway
|
|
IL2 Signaling Pathway
|
|
IL4 Signaling Pathway
|
|
PANTHER Pathway
|
Toll receptor signaling pathway
|
|
Pathway Interaction Database
|
Endogenous TLR signaling
|
|
Reactome
|
Ligand-dependent caspase activation
|
|
Toll Like Receptor 4 (TLR4) Cascade
|
|
MyD88:Mal cascade initiated on plasma membrane
|
|
MyD88-independent TLR3/TLR4 cascade
|
|
TRIF-mediated programmed cell death
|
|
MyD88 deficiency (TLR2/4)
|
|
IRAK4 deficiency (TLR2/4)
|
|
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
|
|
IKK complex recruitment mediated by RIP1
|
|
TRAF6 mediated induction of TAK1 complex
|
|
WikiPathways
|
Toll-like receptor signaling pathway
|
|
Toll-Like Receptors Cascades
|
|
MyD88:Mal cascade initiated on plasma membrane
|
|
MyD88-independent cascade
|
|
Primary Focal Segmental Glomerulosclerosis FSGS
|
|
Spinal Cord Injury
|
|
Corticotropin-releasing hormone
|
|
Pathogenic Escherichia coli infection
|
|
Regulation of toll-like receptor signaling pathway
|
| References |
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032166) |
|---|
| REF 2 | Eritoran insight for influenza treatment. SciBX 6(19); doi:10.1038/scibx.2013.453. May 16 2013 |
|---|
