Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0B1FE
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| Former ID |
DAP001372
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| Drug Name |
Ebselen
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| Synonyms |
Ebselene; Ebseleno; Ebselenum; Harmokisane; Ebselen [INN]; Ebselene [French]; Ebseleno [Spanish]; Ebselenum [Latin]; DR 3305; E 3520; PZ 51; PZ51; RP 60931; DR-3305; PZ-51; SPI-1005; SPI-3005; 2-Phenyl-1,2-benzisoselenazol-3(2H)-one; 2-Phenyl-1,2-benzisoselenazolin-3-one; 2-phenyl-1,2-benzoisoselenazol-3(2H)-one; 2-phenyl-1,2-benzoselenazol-3-one
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| Drug Type |
Small molecular drug
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| Indication | Reperfusion injury and stroke [ICD9: 410, 434.91; ICD10:I21, I22, I61-I63] | Approved | [1] | ||
| Therapeutic Class |
Fibrinolytic Agents
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| Structure |
|
Download2D MOL |
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| Formula |
C13H9NOSe
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| Canonical SMILES |
C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2
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| InChI |
1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
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| InChIKey |
DYEFUKCXAQOFHX-UHFFFAOYSA-N
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| CAS Number |
CAS 60940-34-3
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| PubChem Compound ID | |||||
| PubChem Substance ID |
499808, 613724, 856002, 3151842, 4908335, 8149768, 8152032, 10321966, 11111148, 11111149, 11121407, 11121887, 11336126, 11361365, 11362476, 11365038, 11367600, 11370223, 11370224, 11371858, 11373201, 11373969, 11375762, 11462337, 11466768, 11467888, 11485037, 11486375, 11489257, 11490615, 11492260, 12013066, 14848495, 17405104, 24278417, 26679934, 26751591, 26758640, 29222336, 46386980, 47216849, 47365276, 47515388, 47662368, 47736572, 47810834, 47885488, 47885489, 48259323, 48259324
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| Target and Pathway | |||||
| Target(s) | Serum albumin | Target Info | Binder | [2] | |
| Pathway Interaction Database | FOXA2 and FOXA3 transcription factor networks | ||||
| Reactome | Platelet degranulation | ||||
| Recycling of bile acids and salts | |||||
| HDL-mediated lipid transport | |||||
| Scavenging of heme from plasma | |||||
| WikiPathways | Human Complement System | ||||
| Binding and Uptake of Ligands by Scavenger Receptors | |||||
| Lipid digestion, mobilization, and transport | |||||
| Transport of vitamins, nucleosides, and related molecules | |||||
| Bile acid and bile salt metabolism | |||||
| Folate Metabolism | |||||
| Vitamin B12 Metabolism | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | Advances in ischemic stroke treatment: neuroprotective and combination therapies. Expert Opin Emerg Drugs. 2007 Mar;12(1):97-112. | ||||
| REF 2 | Transport of ebselen in plasma and its transfer to binding sites in the hepatocyte. Biochem Pharmacol. 1994 Sep 15;48(6):1137-44. | ||||
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