| Drug General Information |
| Drug ID |
D0C2KD
|
| Former ID |
DNC004639
|
| Drug Name |
N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C13H17N3O5
|
| Canonical SMILES |
C1=CC(=CC=C1C(=O)NCCCCCC(=O)NO)[N+](=O)[O-]
|
| InChI |
1S/C13H17N3O5/c17-12(15-19)4-2-1-3-9-14-13(18)10-5-7-11(8-6-10)16(20)21/h5-8,19H,1-4,9H2,(H,14,18)(H,15,17)
|
| InChIKey |
GDAAHZPABCCCFD-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Histone deacetylase |
Target Info |
Inhibitor |
[1]
|
|---|
| Histone deacetylase 1 |
Target Info |
Inhibitor |
[2]
|
| Histone deacetylase 6 |
Target Info |
Inhibitor |
[2]
|
| Histone deacetylase 4 |
Target Info |
Inhibitor |
[2]
|
| Histone Deacetylase 8 |
Target Info |
Inhibitor |
[1]
|
| Histone Deacetylase 10 |
Target Info |
Inhibitor |
[1]
|
| Histone deacetylase 2 |
Target Info |
Inhibitor |
[2]
|
|
KEGG Pathway
|
Cell cycle
|
|
Notch signaling pathway
|
|
Thyroid hormone signaling pathway
|
|
Huntington's disease
|
|
Amphetamine addiction
|
|
Alcoholism
|
|
Epstein-Barr virus infection
|
|
Pathways in cancer
|
|
Transcriptional misregulation in cancer
|
|
Viral carcinogenesis
|
|
MicroRNAs in cancer
|
|
Chronic myeloid leukemiahsa05034:Alcoholism
|
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Viral carcinogenesishsa05034:Alcoholism
|
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MicroRNAs in cancerhsa05034:Alcoholism
|
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Viral carcinogenesishsa04110:Cell cycle
|
|
Chronic myeloid leukemia
|
|
NetPath Pathway
|
TCR Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_11:TCR Signaling Pathway
|
|
PANTHER Pathway
|
Wnt signaling pathway
|
|
p53 pathwayP00057:Wnt signaling pathwayP00057:Wnt signaling pathway
|
|
Pathway Interaction Database
|
Regulation of nuclear SMAD2/3 signaling
|
|
Notch signaling pathway
|
|
E2F transcription factor network
|
|
Presenilin action in Notch and Wnt signaling
|
|
Signaling events mediated by HDAC Class I
|
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Regulation of Telomerase
|
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Glucocorticoid receptor regulatory network
|
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Sumoylation by RanBP2 regulates transcriptional repression
|
|
Regulation of Androgen receptor activity
|
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IL3-mediated signaling events
|
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Validated nuclear estrogen receptor alpha network
|
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Retinoic acid receptors-mediated signaling
|
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Hedgehog signaling events mediated by Gli proteins
|
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Regulation of nuclear beta catenin signaling and target gene transcription
|
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Validated targets of C-MYC transcriptional repression
|
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Regulation of retinoblastoma protein
|
|
Notch-mediated HES/HEY networkhdac_classii_pathway:Signaling events mediated by HDAC Class II
|
|
Signaling events mediated by HDAC Class Ihdac_classii_pathway:Signaling events mediated by HDAC Class II
|
|
Signaling events mediated by HDAC Class III
|
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Validated nuclear estrogen receptor alpha networkhdac_classi_pathway:Signaling events mediated by HDAC Class Ihdac_classii_pathway:Signaling events mediated by HDAC Class II
|
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Signaling events mediated by HDAC Class Ismad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
|
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Direct p53 effectors
|
|
Reactome
|
G0 and Early G1
|
|
p75NTR negatively regulates cell cycle via SC1
|
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Formation of the beta-catenin:TCF transactivating complex
|
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NOTCH1 Intracellular Domain Regulates Transcription
|
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SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
|
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Constitutive Signaling by NOTCH1 PEST Domain Mutants
|
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Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
|
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HDACs deacetylate histones
|
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Deactivation of the beta-catenin transactivating complex
|
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NoRC negatively regulates rRNA expression
|
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RNA Polymerase I Transcription Initiation
|
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Factors involved in megakaryocyte development and platelet productionR-HSA-2122947:NOTCH1 Intracellular Domain Regulates Transcription
|
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Assembly of the primary ciliumR-HSA-2122947:NOTCH1 Intracellular Domain Regulates Transcription
|
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Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsR-HSA-2122947:NOTCH1 Intracellular Domain Regulates Transcription
|
|
HDACs deacetylate histonesR-HSA-193670:p75NTR negatively regulates cell cycle via SC1
|
|
Factors involved in megakaryocyte development and platelet production
|
|
WikiPathways
|
SIDS Susceptibility Pathways
|
|
Notch Signaling Pathway
|
|
TGF beta Signaling Pathway
|
|
IL-6 signaling pathway
|
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Apoptosis-related network due to altered Notch3 in ovarian cancer
|
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Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
|
|
Notch Signaling Pathway
|
|
Retinoblastoma (RB) in Cancer
|
|
Neural Crest Differentiation
|
|
TWEAK Signaling Pathway
|
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Integrated Breast Cancer Pathway
|
|
Signalling by NGF
|
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RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
|
|
Mitotic G1-G1/S phases
|
|
Factors involved in megakaryocyte development and platelet production
|
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Cell Cycle
|
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Androgen receptor signaling pathwayWP2858:Ectoderm Differentiation
|
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Cell CycleWP474:Endochondral Ossification
|
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Cardiac Hypertrophic Response
|
|
miR-targeted genes in muscle cell - TarBase
|
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miR-targeted genes in lymphocytes - TarBase
|
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miR-targeted genes in epithelium - TarBase
|
|
TarBasePathway
|
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MicroRNAs in cardiomyocyte hypertrophyWP2377:Integrated Pancreatic Cancer Pathway
|
|
Cell CycleWP61:Notch Signaling Pathway
|
| References |
| REF 1 | J Med Chem. 2002 Feb 14;45(4):753-7.Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. |
|---|
| REF 2 | J Med Chem. 2003 Nov 20;46(24):5097-116.Histone deacetylase inhibitors. |
|---|
