| Drug General Information |
| Drug ID |
D0D7UA
|
| Former ID |
DNC004449
|
| Drug Name |
3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiol
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C15H16O3S2
|
| Canonical SMILES |
C1=CC=C(C=C1)OC2=CC=C(C=C2)S(=O)(=O)CCCS
|
| InChI |
1S/C15H16O3S2/c16-20(17,12-4-11-19)15-9-7-14(8-10-15)18-13-5-2-1-3-6-13/h1-3,5-10,19H,4,11-12H2
|
| InChIKey |
CTVWOVYWOFCAMW-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Interstitial collagenase |
Target Info |
Inhibitor |
[1]
|
|---|
| Neutrophil collagenase |
Target Info |
Inhibitor |
[2]
|
| Collagenase 3 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
PPAR signaling pathway
|
|
Pathways in cancer
|
|
Bladder cancer
|
|
Rheumatoid arthritis
|
|
NetPath Pathway
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IL1 Signaling Pathway
|
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EGFR1 Signaling Pathway
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TWEAK Signaling Pathway
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Wnt Signaling PathwayNetPath_13:IL1 Signaling Pathway
|
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PANTHER Pathway
|
Alzheimer disease-presenilin pathway
|
|
Plasminogen activating cascadeP00004:Alzheimer disease-presenilin pathwayP00004:Alzheimer disease-presenilin pathway
|
|
Plasminogen activating cascade
|
|
Pathway Interaction Database
|
Endothelins
|
|
Validated transcriptional targets of AP1 family members Fra1 and Fra2
|
|
Glucocorticoid receptor regulatory network
|
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AP-1 transcription factor network
|
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Syndecan-1-mediated signaling eventsupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
|
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Reactome
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Collagen degradation
|
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Degradation of the extracellular matrix
|
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Activation of Matrix Metalloproteinases
|
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Basigin interactions
|
|
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)R-HSA-1442490:Collagen degradation
|
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Activation of Matrix MetalloproteinasesR-HSA-1442490:Collagen degradation
|
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Assembly of collagen fibrils and other multimeric structures
|
|
WikiPathways
|
TGF beta Signaling Pathway
|
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Bladder Cancer
|
|
Activation of Matrix Metalloproteinases
|
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Degradation of collagen
|
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Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
|
|
Oncostatin M Signaling Pathway
|
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Prostate Cancer
|
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Integrated Breast Cancer Pathway
|
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Integrated Cancer pathway
|
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Cell surface interactions at the vascular wall
|
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Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
|
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Matrix MetalloproteinasesWP474:Endochondral Ossification
|
|
AGE/RAGE pathway
|
|
Matrix Metalloproteinases
|
| References |
| REF 1 | Bioorg Med Chem Lett. 1999 Apr 5;9(7):943-8.Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols. |
|---|
| REF 2 | Bioorg Med Chem Lett. 1999 Jul 5;9(13):1757-60.Synthesis and identification of conformationally constrained selective MMP inhibitors. |
|---|
