Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0G4RG
|
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| Former ID |
DNC004791
|
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| Drug Name |
4-Morpholin-4-yl-benzo[h]chromen-2-one
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C17H15NO3
|
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| Canonical SMILES |
C1COCCN1C2=CC(=O)OC3=C2C=CC4=CC=CC=C43
|
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| InChI |
1S/C17H15NO3/c19-16-11-15(18-7-9-20-10-8-18)14-6-5-12-3-1-2-4-13(12)17(14)21-16/h1-6,11H,7-10H2
|
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| InChIKey |
QPPKEHFJUVBRAD-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | DNA-dependent protein kinase catalytic subunit | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Non-homologous end-joining | ||||
| Cell cycle | |||||
| NetPath Pathway | IL1 Signaling Pathway | ||||
| Pathway Interaction Database | DNA-PK pathway in nonhomologous end joining | ||||
| Coregulation of Androgen receptor activity | |||||
| Class I PI3K signaling events mediated by Akt | |||||
| BARD1 signaling events | |||||
| Reactome | Nonhomologous End-Joining (NHEJ) | ||||
| WikiPathways | DNA Damage Response | ||||
| Non-homologous end joining | |||||
| FAS pathway and Stress induction of HSP regulation | |||||
| Cytosolic sensors of pathogen-associated DNA | |||||
| Retinoblastoma (RB) in Cancer | |||||
| Prostate Cancer | |||||
| Double-Strand Break Repair | |||||
| Cell Cycle | |||||
| miRNA Regulation of DNA Damage Response | |||||
| References | |||||
| REF 1 | J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. | ||||
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