Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0I0NP
|
||||
| Former ID |
DNC001627
|
||||
| Drug Name |
SL125
|
||||
| Indication | Congestive heart failure; Myocardial fibrosis; Hyperaldosteronism [ICD9: 255.1, 425.0, 425.3, 428, 428.0, 709.2; ICD10:E26, I42.0, I42.5, I50, L90.5] | Investigative | [1] | ||
| Target and Pathway | |||||
| Target(s) | Cytochrome P450 11B1, mitochondrial | Target Info | Inhibitor | [1] | |
| BioCyc Pathway | Superpathway of steroid hormone biosynthesis | ||||
| Glucocorticoid biosynthesis | |||||
| Mineralocorticoid biosynthesis | |||||
| KEGG Pathway | Steroid hormone biosynthesis | ||||
| Metabolic pathways | |||||
| PathWhiz Pathway | Steroidogenesis | ||||
| Reactome | Glucocorticoid biosynthesis | ||||
| Endogenous sterols | |||||
| WikiPathways | Metapathway biotransformation | ||||
| Oxidation by Cytochrome P450 | |||||
| Metabolism of steroid hormones and vitamin D | |||||
| Corticotropin-releasing hormone | |||||
| References | |||||
| REF 1 | Reduction of cell proliferation induced by PD166866: an inhibitor of the basic fibroblast growth factor. J Exp Clin Cancer Res. 2007 Sep;26(3):405-9. | ||||
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