Drug General Information
Drug ID	D0ID3W
Former ID	DIB001357
Drug Name	GW-813893
Synonyms	Factor Xa inhibitors, GSK; Factor Xa inhibitors, GlaxoSmithKline; 813893
Indication	Thromboembolism [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82]		Phase 2	[1]
Company	GlaxoSmithKline plc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	N1(C(=O)[C@H](CC1)NS(=O)(=O)/C=C/c1sc(cc1)Cl)[C@H](C(=O<br />)N1CCOCC1)C
Target and Pathway
Target(s)	Coagulation factor Xa	Target Info	Inhibitor	[2], [3]
KEGG Pathway	Complement and coagulation cascades
PANTHER Pathway	Blood coagulation
Pathway Interaction Database	Beta2 integrin cell surface interactions
PathWhiz Pathway	Coagulation
Reactome	Extrinsic Pathway of Fibrin Clot Formation
	Intrinsic Pathway of Fibrin Clot Formation
	Common Pathway of Fibrin Clot Formation
	Gamma-carboxylation of protein precursors
	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
	Removal of aminoterminal propeptides from gamma-carboxylated proteins
WikiPathways	Complement and Coagulation Cascades
	Human Complement System
	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
	Blood Clotting Cascade
	Formation of Fibrin Clot (Clotting Cascade)
References
REF 1	ClinicalTrials.gov (NCT00541320) Phase IIa Venous Thromboembolism (VTE) Prevention Study In Total Knee Replacement (TKR). U.S. National Institutes of Health.
REF 2	Venous thromboembolism in the patient with cancer: focus on burden of disease and benefits of thromboprophylaxis. Cancer. 2011 Apr 1;117(7):1334-49.
REF 3	Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7.

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