| Drug General Information |
| Drug ID |
D0J8PY
|
| Former ID |
DNC011531
|
| Drug Name |
4-Benzyl-1-(2-phenoxy-ethyl)-piperidine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C20H25NO
|
| Canonical SMILES |
C1CN(CCC1CC2=CC=CC=C2)CCOC3=CC=CC=C3
|
| InChI |
1S/C20H25NO/c1-3-7-18(8-4-1)17-19-11-13-21(14-12-19)15-16-22-20-9-5-2-6-10-20/h1-10,19H,11-17H2
|
| InChIKey |
HRBKFQYSVXXYDE-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Glutamate [NMDA] receptor subunit epsilon 2 |
Target Info |
Inhibitor |
[1]
|
|---|
| NMDA receptor subunit NR1 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
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cAMP signaling pathway
|
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Neuroactive ligand-receptor interaction
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Circadian entrainment
|
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Long-term potentiation
|
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Glutamatergic synapse
|
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Dopaminergic synapse
|
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Alzheimer's disease
|
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Amyotrophic lateral sclerosis (ALS)
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Huntington's disease
|
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Cocaine addiction
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Amphetamine addiction
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Nicotine addiction
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Alcoholism
|
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Systemic lupus erythematosushsa04014:Ras signaling pathway
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Calcium signaling pathway
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PANTHER Pathway
|
Huntington disease
|
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Ionotropic glutamate receptor pathway
|
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Metabotropic glutamate receptor group III pathway
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Metabotropic glutamate receptor group I pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
|
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
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Pathway Interaction Database
|
ErbB4 signaling events
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Reelin signaling pathway
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Reactome
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EPHB-mediated forward signaling
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Unblocking of NMDA receptor, glutamate binding and activation
|
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CREB phosphorylation through the activation of CaMKII
|
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Ras activation uopn Ca2+ infux through NMDA receptor
|
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RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
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RAF/MAP kinase cascade
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WikiPathways
|
Hypothetical Network for Drug Addiction
|
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
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BDNF signaling pathwayWP706:SIDS Susceptibility Pathways
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Spinal Cord Injury
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BDNF signaling pathway
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Alzheimers Disease
|
| References |
| REF 1 | J Med Chem. 1999 Jul 29;42(15):2993-3000.4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. |
|---|
