Drug General Information |
Drug ID |
D0P0GT
|
Former ID |
DNC002630
|
Drug Name |
Cycloleucine
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C6H11NO2
|
Canonical SMILES |
C1CCC(C1)(C(=O)O)N
|
InChI |
1S/C6H11NO2/c7-6(5(8)9)3-1-2-4-6/h1-4,7H2,(H,8,9)
|
InChIKey |
NILQLFBWTXNUOE-UHFFFAOYSA-N
|
CAS Number |
CAS 52-52-8
|
PubChem Compound ID |
|
PubChem Substance ID |
6689, 67889, 610376, 3131911, 6436540, 7407703, 7885664, 8136892, 8149835, 8151856, 10525255, 11335898, 11361137, 11364162, 11366724, 11369286, 11372786, 11373858, 11377448, 11404465, 11447323, 11462109, 11484598, 11488747, 11491329, 11492155, 11495082, 15194490, 24846087, 24890914, 26612314, 26679236, 26748625, 26748626, 26756618, 29222054, 46393608, 46505671, 47515338, 47885435, 48185016, 48259251, 48334508, 48422156, 48435965, 49854394, 50122828, 51073752, 57321507, 57777606
|
Target and Pathway |
Target(s) |
NMDA receptor subunit NR1 |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
|
Ras signaling pathway
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Rap1 signaling pathway
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Calcium signaling pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Circadian entrainment
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Long-term potentiation
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Glutamatergic synapse
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Alzheimer's disease
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Amyotrophic lateral sclerosis (ALS)
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Huntington's disease
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Cocaine addiction
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Amphetamine addiction
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Nicotine addiction
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Alcoholism
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PANTHER Pathway
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Huntington disease
|
Ionotropic glutamate receptor pathway
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Metabotropic glutamate receptor group III pathway
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Metabotropic glutamate receptor group I pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
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Reactome
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EPHB-mediated forward signaling
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Unblocking of NMDA receptor, glutamate binding and activation
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CREB phosphorylation through the activation of CaMKII
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Ras activation uopn Ca2+ infux through NMDA receptor
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RAF/MAP kinase cascade
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WikiPathways
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SIDS Susceptibility Pathways
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Hypothetical Network for Drug Addiction
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
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Spinal Cord Injury
|
BDNF signaling pathway
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Alzheimers Disease
|
References |
REF 1 | Effects of D-cycloserine and cycloleucine, ligands for the <span class="caps">NMDA</span>-associated strychnine-insensitive glycine site, on brain-stimulation reward and spontaneous locomotion. Pharmacol Biochem Behav. 1990 Aug;36(4):735-8. |