| Drug General Information |
| Drug ID |
D0Q0BK
|
| Former ID |
DNC011032
|
| Drug Name |
3-Fluoro-4'-(pyridin-4-ylmethyl)biphenyl-4-ol
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C18H14FNO
|
| Canonical SMILES |
C1=CC(=CC=C1CC2=CC=NC=C2)C3=CC(=C(C=C3)O)F
|
| InChI |
1S/C18H14FNO/c19-17-12-16(5-6-18(17)21)15-3-1-13(2-4-15)11-14-7-9-20-10-8-14/h1-10,12,21H,11H2
|
| InChIKey |
SFFLHOMUFWFHRI-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Cytochrome P450 19 |
Target Info |
Inhibitor |
[1]
|
|---|
| 17 alpha-hydroxylase-C17, 20-lyase |
Target Info |
Inhibitor |
[1]
|
| Cytochrome P450 11B1, mitochondrial |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Superpathway of steroid hormone biosynthesis
|
|
Estradiol biosynthesis II
|
|
Estradiol biosynthesis IPWY-7305:Superpathway of steroid hormone biosynthesis
|
|
Glucocorticoid biosynthesis
|
|
Androgen biosynthesisPWY-7305:Superpathway of steroid hormone biosynthesis
|
|
Mineralocorticoid biosynthesis
|
|
KEGG Pathway
|
Steroid hormone biosynthesis
|
|
Metabolic pathways
|
|
Ovarian steroidogenesishsa00140:Steroid hormone biosynthesis
|
|
Ovarian steroidogenesis
|
|
Prolactin signaling pathwayhsa00140:Steroid hormone biosynthesis
|
|
NetPath Pathway
|
FSH Signaling Pathway
|
|
PANTHER Pathway
|
Androgen/estrogene/progesterone biosynthesis
|
|
PathWhiz Pathway
|
Androgen and Estrogen MetabolismPW000045:Androgen and Estrogen Metabolism
|
|
SteroidogenesisPW000141:Steroidogenesis
|
|
Reactome
|
Endogenous sterolsR-HSA-193048:Androgen biosynthesis
|
|
Glucocorticoid biosynthesis
|
|
Endogenous sterolsR-HSA-194002:Glucocorticoid biosynthesis
|
|
Endogenous sterols
|
|
WikiPathways
|
Metapathway biotransformation
|
|
Tryptophan metabolism
|
|
Oxidation by Cytochrome P450
|
|
Ovarian Infertility Genes
|
|
Metabolism of steroid hormones and vitamin D
|
|
FSH signaling pathway
|
|
Integrated Breast Cancer Pathway
|
|
Phase 1 - Functionalization of compoundsWP702:Metapathway biotransformation
|
|
Steroid Biosynthesis
|
|
Glucocorticoid & Mineralcorticoid Metabolism
|
|
Prostate Cancer
|
|
Corticotropin-releasing hormone
|
| References |
| REF 1 | J Med Chem. 2010 Aug 12;53(15):5749-58.Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer. |
|---|
