| Drug General Information |
| Drug ID |
D0Q6QW
|
| Former ID |
DNC012275
|
| Drug Name |
3-Benzoyl-7-chloro-4-hydroxy-1H-quinolin-2-one
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H10ClNO3
|
| Canonical SMILES |
C1=CC=C(C=C1)C(=C2C(=O)C3=C(C=C(C=C3)Cl)NC2=O)O
|
| InChI |
1S/C16H10ClNO3/c17-10-6-7-11-12(8-10)18-16(21)13(15(11)20)14(19)9-4-2-1-3-5-9/h1-8,19H,(H,18,21)/b14-13+
|
| InChIKey |
ZKYXZOTZWTVLIE-BUHFOSPRSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
NMDA receptor subunit NR1 |
Target Info |
Inhibitor |
[1]
|
|---|
| Glutamate [NMDA] receptor subunit epsilon 1 |
Target Info |
Inhibitor |
[1]
|
| Glutamate [NMDA] receptor subunit epsilon 2 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Ras signaling pathway
|
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Rap1 signaling pathway
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Calcium signaling pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
|
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Circadian entrainment
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Long-term potentiation
|
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Glutamatergic synapse
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Alzheimer's disease
|
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Amyotrophic lateral sclerosis (ALS)
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Huntington's disease
|
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Cocaine addiction
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Amphetamine addiction
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Nicotine addiction
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Alcoholismhsa04014:Ras signaling pathway
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Dopaminergic synapse
|
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Alcoholism
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Systemic lupus erythematosushsa04014:Ras signaling pathway
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Systemic lupus erythematosus
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PANTHER Pathway
|
Huntington disease
|
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Ionotropic glutamate receptor pathway
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Metabotropic glutamate receptor group III pathway
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Metabotropic glutamate receptor group I pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
|
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
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Pathway Interaction Database
|
Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events
|
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Reelin signaling pathway
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Reactome
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EPHB-mediated forward signaling
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Unblocking of NMDA receptor, glutamate binding and activation
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CREB phosphorylation through the activation of CaMKII
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Ras activation uopn Ca2+ infux through NMDA receptor
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RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation
|
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RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
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RAF/MAP kinase cascade
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WikiPathways
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SIDS Susceptibility Pathways
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Hypothetical Network for Drug Addiction
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
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Spinal Cord Injury
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BDNF signaling pathway
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Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
|
| References |
| REF 1 | Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). |
|---|
