| Drug General Information |
| Drug ID |
D0S3TJ
|
| Former ID |
DNC003254
|
| Drug Name |
6-MORPHOLIN-4-YL-9H-PURINE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C9H11N5O
|
| Canonical SMILES |
C1COCCN1C2=NC=NC3=C2NC=N3
|
| InChI |
1S/C9H11N5O/c1-3-15-4-2-14(1)9-7-8(11-5-10-7)12-6-13-9/h5-6H,1-4H2,(H,10,11,12,13)
|
| InChIKey |
MEOMXKNIFWDDGZ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
576076, 862467, 3277739, 4719452, 7969883, 24905384, 43131798, 47737194, 47811423, 50898243, 57706320, 60732307, 81116192, 84981749, 85266831, 89460432, 99445251, 103133387, 103578276, 104363433, 105975001, 117358207, 117522217, 124822178, 125780793, 128584441, 131035026, 131385174, 134381908, 135032485, 137083630, 137858716, 138431631, 143893198, 162103452, 162829870, 164223240, 170198942, 170481504, 179077094, 179334770, 181849705, 215774649, 223579483, 225020709, 225161114, 225249271, 226672508, 241058492, 252456112
|
| Target and Pathway |
| Target(s) |
Serine/threonine-protein kinase Chk1 |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
|
Cell cycle
|
|
p53 signaling pathway
|
|
HTLV-I infection
|
|
Viral carcinogenesis
|
|
Pathway Interaction Database
|
Fanconi anemia pathway
|
|
p73 transcription factor network
|
|
ATR signaling pathway
|
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Circadian rhythm pathway
|
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p53 pathway
|
|
Reactome
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Activation of ATR in response to replication stress
|
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Processing of DNA double-strand break ends
|
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Presynaptic phase of homologous DNA pairing and strand exchange
|
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G2/M DNA damage checkpoint
|
|
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
|
|
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
|
|
WikiPathways
|
DNA Damage Response
|
|
Signaling by SCF-KIT
|
|
ATM Signaling Pathway
|
|
Retinoblastoma (RB) in Cancer
|
|
Integrated Pancreatic Cancer Pathway
|
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Prostate Cancer
|
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Integrated Breast Cancer Pathway
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Integrated Cancer pathway
|
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Cell Cycle
|
|
Cell Cycle Checkpoints
|
|
miRNA Regulation of DNA Damage Response
|
| References |
| REF 1 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. |
|---|
