Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0SG0N
|
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| Former ID |
DIB000694
|
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| Drug Name |
DB-200
|
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| Synonyms |
DB-200; DB-200 series (topical, psoriasis); CPT-1 inhibitor (topical, psoriasis), DARA; DB-200 series (topical, psoriasis), DARA BioSciences
|
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| Indication | Psoriasis [ICD9: 696; ICD10:L40] | Terminated | [1] | ||
| Company |
DARA BioSciences
|
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| Target and Pathway | |||||
| Target(s) | Carnitine O-palmitoyltransferase I | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Fatty acid degradation | ||||
| Fatty acid metabolism | |||||
| PPAR signaling pathway | |||||
| AMPK signaling pathway | |||||
| Adipocytokine signaling pathway | |||||
| Glucagon signaling pathway | |||||
| PathWhiz Pathway | Fatty acid Metabolism | ||||
| Reactome | RORA activates gene expression | ||||
| PPARA activates gene expression | |||||
| Import of palmitoyl-CoA into the mitochondrial matrix | |||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Mitochondrial LC-Fatty Acid Beta-Oxidation | |||||
| Nuclear Receptors Meta-Pathway | |||||
| PPAR Alpha Pathway | |||||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |||||
| Circadian Clock | |||||
| Fatty Acid Beta Oxidation | |||||
| AMPK Signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026687) | ||||
| REF 2 | Comparison of the effects of carnitine palmitoyltransferase-1 and -2 inhibitors on rat heart hypertrophy. Cardioscience. 1994 Sep;5(3):193-7. | ||||
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