Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0T8QB
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| Former ID |
DNC010571
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| Drug Name |
GLYCYRRHIZIN
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| Drug Type |
Small molecular drug
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| Indication | Influenza virus [ICD10:J11.1] | Phase 3 | [1], [2] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C42H62O16
|
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| InChI |
InChI=1S/C42H62O16/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54)/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+/m0/s1
|
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| InChIKey |
LPLVUJXQOOQHMX-QWBHMCJMSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
595979, 8145710, 8161234, 12014953, 14767124, 14889369, 29282971, 49974013, 53789412, 57328816, 80458755, 87570348, 93165815, 104069368, 104225159, 104253562, 104335876, 117542241, 118046163, 119525684, 124360077, 124757704, 125164508, 126592383, 134981322, 135985736, 137005264, 137174069, 144205073, 144206976, 144213802, 152032505, 152108764, 160703999, 162037865, 162176852, 163614442, 163883554, 175265976, 178101402, 179316054, 184545284, 196378207, 223673136, 223721543, 223800488, 226407764, 249839445, 252216692, 252391202
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| SuperDrug ATC ID |
A05BA08
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| Target and Pathway | |||||
| Target(s) | Corticosteroid 11-beta-dehydrogenase, isozyme 1 | Target Info | Inhibitor | [3] | |
| KEGG Pathway | Steroid hormone biosynthesis | ||||
| Metabolism of xenobiotics by cytochrome P450 | |||||
| Metabolic pathways | |||||
| Chemical carcinogenesis | |||||
| NetPath Pathway | IL1 Signaling Pathway | ||||
| FSH Signaling Pathway | |||||
| PathWhiz Pathway | Steroidogenesis | ||||
| Reactome | Glucocorticoid biosynthesis | ||||
| WikiPathways | Prostaglandin Synthesis and Regulation | ||||
| Metabolism of steroid hormones and vitamin D | |||||
| Glucocorticoid & Mineralcorticoid Metabolism | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4688). | ||||
| REF 2 | ClinicalTrials.gov (NCT01342185) Efficacy of Medical Ozone Therapy in Patients With Chronic Hepatitis B. U.S. National Institutes of Health. | ||||
| REF 3 | Bioorg Med Chem. 2009 Aug 1;17(15):5722-32. Epub 2009 Jun 12.Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes. | ||||
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