| Drug General Information |
| Drug ID |
D0U4JW
|
| Former ID |
DNC009823
|
| Drug Name |
1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine
|
| Drug Type |
Small molecular drug
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| Indication |
Discovery agent
|
Investigative |
[1]
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| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C13H10N2O2S
|
| Canonical SMILES |
C1=CC=C(C=C1)S(=O)(=O)N2C=CC3=C2C=CC=N3
|
| InChI |
1S/C13H10N2O2S/c16-18(17,11-5-2-1-3-6-11)15-10-8-12-13(15)7-4-9-14-12/h1-10H
|
| InChIKey |
HGOGRVVSSAWHTO-UHFFFAOYSA-N
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| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Hepatocyte growth factor receptor |
Target Info |
Inhibitor |
[1]
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KEGG Pathway
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Ras signaling pathway
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Rap1 signaling pathway
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Cytokine-cytokine receptor interaction
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Endocytosis
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PI3K-Akt signaling pathway
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Axon guidance
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Focal adhesion
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Adherens junction
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Bacterial invasion of epithelial cells
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Epithelial cell signaling in Helicobacter pylori infection
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Malaria
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Pathways in cancer
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Transcriptional misregulation in cancer
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Proteoglycans in cancer
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MicroRNAs in cancer
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Renal cell carcinoma
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Melanoma
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Central carbon metabolism in cancer
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Pathway Interaction Database
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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Arf6 signaling events
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Signaling events mediated by TCPTP
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Posttranslational regulation of adherens junction stability and dissassembly
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Direct p53 effectors
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Syndecan-1-mediated signaling events
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Stabilization and expansion of the E-cadherin adherens junction
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a6b1 and a6b4 Integrin signaling
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FGF signaling pathway
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Regulation of retinoblastoma protein
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Reactome
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Sema4D mediated inhibition of cell attachment and migration
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WikiPathways
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TGF beta Signaling Pathway
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Signaling of Hepatocyte Growth Factor Receptor
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Focal Adhesion
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Extracellular vesicle-mediated signaling in recipient cells
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Signaling Pathways in Glioblastoma
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miR-targeted genes in squamous cell - TarBase
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miR-targeted genes in muscle cell - TarBase
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miR-targeted genes in lymphocytes - TarBase
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miR-targeted genes in epithelium - TarBase
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Semaphorin interactions
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| References |
| REF 1 | Bioorg Med Chem Lett. 2009 May 15;19(10):2780-4. Epub 2009 Mar 27.Discovery of 4-azaindoles as novel inhibitors of c-Met kinase. |
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