Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0V5TC
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| Former ID |
DNC008515
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| Drug Name |
1-(3-nitropyridin-2-yl)-4-tosylpiperazine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C16H18N4O4S
|
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| Canonical SMILES |
CC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C3=C(C=CC=N3)[N+](=O)[<br />O-]
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| InChI |
1S/C16H18N4O4S/c1-13-4-6-14(7-5-13)25(23,24)19-11-9-18(10-12-19)16-15(20(21)22)3-2-8-17-16/h2-8H,9-12H2,1H3
|
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| InChIKey |
JYSIWWVOXFISJK-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Corticosteroid 11-beta-dehydrogenase, isozyme 1 | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Steroid hormone biosynthesis | ||||
| Metabolism of xenobiotics by cytochrome P450 | |||||
| Metabolic pathways | |||||
| Chemical carcinogenesis | |||||
| NetPath Pathway | IL1 Signaling Pathway | ||||
| FSH Signaling Pathway | |||||
| PathWhiz Pathway | Steroidogenesis | ||||
| Reactome | Glucocorticoid biosynthesis | ||||
| WikiPathways | Prostaglandin Synthesis and Regulation | ||||
| Metabolism of steroid hormones and vitamin D | |||||
| Glucocorticoid & Mineralcorticoid Metabolism | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2008 Jun 15;18(12):3513-6. Epub 2008 May 10.Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). | ||||
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