Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0V9VG
|
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| Former ID |
DIB014941
|
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| Drug Name |
BMS-927711
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| Drug Type |
Small molecular drug
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| Indication | Migraine [ICD9: 346; ICD10:G43] | Phase 2 | [1] | ||
| Company |
Labrys Biologics
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C28H28F2N6O3
|
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| Canonical SMILES |
N[C@H]1[C@@H](CC[C@@H](OC(=O)N2CCC(CC2)N3C(=O)Nc4ncccc3<br />4)c5ncccc15)c6cccc(F)c6F
|
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| InChI |
1S/C28H28F2N6O3/c29-20-6-1-4-17(23(20)30)18-8-9-22(25-19(24(18)31)5-2-12-32-25)39-28(38)35-14-10-16(11-15-35)36-21-7-3-13-33-26(21)34-27(36)37/h1-7,12-13,16,18,22,24H,8-11,14-15,31H2,(H,33,34,37)/t18-,22+,24-/m0/s1
|
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| InChIKey |
KRNAOFGYEFKHPB-ANJVHQHFSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Calcitoningene-related peptide type 1 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Vascular smooth muscle contraction | |||||
| Reactome | G alpha (s) signalling events | ||||
| Calcitonin-like ligand receptors | |||||
| WikiPathways | GPCRs, Class B Secretin-like | ||||
| Endothelin Pathways | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT01430442) Dose Ranging Study of a Drug for the Treatment of Acute Migraine. U.S. National Institutes of Health. | ||||
| REF 2 | BMS-927711 for the acute treatment of migraine: a double-blind, randomized, placebo controlled, dose-ranging trial. Cephalalgia. 2014 Feb;34(2):114-25. | ||||
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