Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0VH3H
|
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| Former ID |
DCL001246
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| Drug Name |
TM38837
|
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| Drug Type |
Small molecular drug
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| Indication | Obesity; Metabolic disorders [ICD9: 270-279, 278; ICD10:E66, E70-E89] | Phase 1 | [1], [2] | ||
| Company |
7TM Pharma A/S
|
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| Structure |
|
Download2D MOL |
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| Formula |
C30H25Cl2F3N4OS
|
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| InChI |
InChI=1S/C30H25Cl2F3N4OS/c1-2-23-27(29(40)37-38-16-4-3-5-17-38)36-39(25-14-11-21(31)18-24(25)32)28(23)26-15-13-22(41-26)12-8-19-6-9-20(10-7-19)30(33,34)35/h6-7,9-11,13-15,18H,2-5,16-17H2,1H3,(H,37,40)
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| InChIKey |
VQOCBFYUDSBDCZ-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Cannabinoid receptor 1 | Target Info | Antagonist | [2] | |
| KEGG Pathway | Rap1 signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Retrograde endocannabinoid signaling | |||||
| PANTHER Pathway | Endogenous cannabinoid signaling | ||||
| Pathway Interaction Database | N-cadherin signaling events | ||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Small Ligand GPCRs | |||||
| BDNF signaling pathway | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8705). | ||||
| REF 2 | 2011 Pipeline of 7TM Pharma. | ||||
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