| Drug General Information |
| Drug ID |
D0W4FF
|
| Former ID |
DNC004092
|
| Drug Name |
ML-3403
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C23H21FN4S
|
| InChI |
InChI=1S/C23H21FN4S/c1-15(16-6-4-3-5-7-16)26-20-14-18(12-13-25-20)22-21(27-23(28-22)29-2)17-8-10-19(24)11-9-17/h3-15H,1-2H3,(H,25,26)(H,27,28)
|
| InChIKey |
VXPWQNBKEIVYIS-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
10318936, 14781534, 26759302, 26759306, 43014005, 48094517, 53800615, 53800617, 78058967, 99302794, 103332017, 104021977, 114518082, 134222987, 134341297, 163687545, 163687549, 175607501, 178102636, 179236145, 196376150, 208264834, 228963874, 239976384, 241377070, 245215424, 249279967, 249618212, 252158193
|
| Target and Pathway |
| Target(s) |
MAP kinase p38 |
Target Info |
Inhibitor |
[2]
|
|---|
| Cytochrome P450 3A4 |
Target Info |
Inhibitor |
[2]
|
| Mitogen-activated protein kinase 14 |
Target Info |
Inhibitor |
[2]
|
| Mitogen-activated protein kinase 11 |
Target Info |
Inhibitor |
[2]
|
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KEGG Pathway
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MAPK signaling pathway
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Rap1 signaling pathway
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FoxO signaling pathway
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Sphingolipid signaling pathway
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Oocyte meiosis
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Adrenergic signaling in cardiomyocytes
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VEGF signaling pathway
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Osteoclast differentiation
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Signaling pathways regulating pluripotency of stem cells
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Platelet activation
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Toll-like receptor signaling pathway
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NOD-like receptor signaling pathway
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RIG-I-like receptor signaling pathway
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T cell receptor signaling pathway
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Fc epsilon RI signaling pathway
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TNF signaling pathway
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Leukocyte transendothelial migration
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Neurotrophin signaling pathway
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Retrograde endocannabinoid signaling
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Dopaminergic synapse
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Inflammatory mediator regulation of TRP channels
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GnRH signaling pathway
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Progesterone-mediated oocyte maturation
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Prolactin signaling pathway
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Amyotrophic lateral sclerosis (ALS)
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Epithelial cell signaling in Helicobacter pylori infection
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Shigellosis
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Salmonella infection
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Pertussis
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Leishmaniasis
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Chagas disease (American trypanosomiasis)
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Toxoplasmosis
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Tuberculosis
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Hepatitis C
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Influenza A
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Epstein-Barr virus infection
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Proteoglycans in cancerhsa00140:Steroid hormone biosynthesis
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Linoleic acid metabolism
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Retinol metabolism
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Metabolism of xenobiotics by cytochrome P450
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Drug metabolism - cytochrome P450
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Drug metabolism - other enzymes
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Metabolic pathways
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Bile secretion
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Chemical carcinogenesishsa04010:MAPK signaling pathway
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Proteoglycans in cancerhsa04010:MAPK signaling pathway
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Proteoglycans in cancer
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NetPath Pathway
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TCR Signaling PathwayNetPath_17:IL5 Signaling Pathway
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FSH Signaling Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Alzheimer disease-amyloid secretase pathway
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B cell activation
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EGF receptor signaling pathway
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FGF signaling pathway
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Interferon-gamma signaling pathway
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Oxidative stress response
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Parkinson disease
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TGF-beta signaling pathway
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Ras Pathway
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p53 pathway feedback loops 2
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p38 MAPK pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Angiogenesis
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Toll receptor signaling pathway
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VEGF signaling pathway
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p38 MAPK pathway
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CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
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Pathway Interaction Database
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RhoA signaling pathway
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Signaling mediated by p38-gamma and p38-deltaendothelinpathway:Endothelins
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BCR signaling pathway
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p73 transcription factor network
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p38 MAPK signaling pathway
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Atypical NF-kappaB pathway
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IL4-mediated signaling events
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CD40/CD40L signaling
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IL12-mediated signaling events
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Regulation of p38-alpha and p38-beta
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CDC42 signaling events
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Angiopoietin receptor Tie2-mediated signaling
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FAS (CD95) signaling pathway
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Thromboxane A2 receptor signaling
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Glucocorticoid receptor regulatory network
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IL2-mediated signaling events
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Rapid glucocorticoid signaling
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Regulation of Androgen receptor activity
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ATF-2 transcription factor network
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IL6-mediated signaling events
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p38 signaling mediated by MAPKAP kinases
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Retinoic acid receptors-mediated signaling
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CXCR3-mediated signaling events
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Signaling mediated by p38-alpha and p38-beta
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EPO signaling pathway
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Signaling events mediated by VEGFR1 and VEGFR2
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p53 pathway
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S1P2 pathway
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Trk receptor signaling mediated by the MAPK pathway
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VEGFR3 signaling in lymphatic endothelium
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FGF signaling pathway
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RAC1 signaling pathway
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Regulation of retinoblastoma proteinp73pathway:p73 transcription factor network
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Plasma membrane estrogen receptor signaling
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Regulation of retinoblastoma protein
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PathWhiz Pathway
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Caffeine Metabolism
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Retinol MetabolismPW000453:Fc Epsilon Receptor I Signaling in Mast CellsPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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Reactome
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NOD1/2 Signaling Pathway
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p38MAPK events
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Activation of PPARGC1A (PGC-1alpha) by phosphorylation
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CDO in myogenesis
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DSCAM interactions
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VEGFA-VEGFR2 PathwayR-HSA-211981:Xenobiotics
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Aflatoxin activation and detoxificationR-HSA-168638:NOD1/2 Signaling Pathway
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ERK/MAPK targets
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Oxidative Stress Induced Senescence
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ADP signalling through P2Y purinoceptor 1
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Platelet sensitization by LDL
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VEGFA-VEGFR2 Pathway
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activated TAK1 mediates p38 MAPK activation
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Activation of the AP-1 family of transcription factors
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KSRP (KHSRP) binds and destabilizes mRNAR-HSA-168638:NOD1/2 Signaling Pathway
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KSRP (KHSRP) binds and destabilizes mRNA
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WikiPathways
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Toll-like receptor signaling pathway
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Insulin Signaling
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MAPK Cascade
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MAPK Signaling Pathway
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Nanoparticle-mediated activation of receptor signaling
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Signal Transduction of S1P Receptor
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Parkinsons Disease Pathway
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miR-targeted genes in muscle cell - TarBase
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miR-targeted genes in lymphocytes - TarBase
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NGF signalling via TRKA from the plasma membrane
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Myogenesis
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Integrin-mediated Cell Adhesion
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DSCAM interactions
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Regulation of toll-like receptor signaling pathwayWP702:Metapathway biotransformation
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Aflatoxin B1 metabolism
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Estrogen metabolism
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Benzo(a)pyrene metabolism
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Tamoxifen metabolism
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Tryptophan metabolism
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Oxidation by Cytochrome P450
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Nuclear Receptors in Lipid Metabolism and Toxicity
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Nuclear Receptors Meta-Pathway
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Farnesoid X Receptor Pathway
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Vitamin D Receptor Pathway
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Felbamate Metabolism
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Lidocaine metabolism
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Nifedipine Activity
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Colchicine Metabolic Pathway
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Irinotecan Pathway
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Drug Induction of Bile Acid Pathway
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Fatty Acid Omega Oxidation
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Codeine and Morphine MetabolismWP75:Toll-like receptor signaling pathway
|
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Monoamine Transport
|
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Serotonin HTR1 Group and FOS Pathway
|
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TCR Signaling Pathway
|
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Senescence and Autophagy in Cancer
|
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Interferon type I signaling pathways
|
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EGF/EGFR Signaling Pathway
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Oxidative Stress
|
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p38 MAPK Signaling Pathway
|
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IL-4 Signaling Pathway
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TGF beta Signaling Pathway
|
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Kit receptor signaling pathway
|
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Cardiac Hypertrophic Response
|
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MAP kinase activation in TLR cascade
|
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Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
|
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Structural Pathway of Interleukin 1 (IL-1)
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JAK/STAT
|
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Amyotrophic lateral sclerosis (ALS)
|
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Alpha 6 Beta 4 signaling pathway
|
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Cardiac Progenitor Differentiation
|
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BDNF signaling pathway
|
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Integrated Pancreatic Cancer Pathway
|
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Oncostatin M Signaling Pathway
|
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Corticotropin-releasing hormone
|
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AGE/RAGE pathway
|
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B Cell Receptor Signaling Pathway
|
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Prostate Cancer
|
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TSLP Signaling Pathway
|
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TWEAK Signaling Pathway
|
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FSH signaling pathway
|
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Leptin signaling pathway
|
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RANKL/RANK Signaling Pathway
|
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miR-targeted genes in leukocytes - TarBase
|
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miR-targeted genes in epithelium - TarBase
|
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IL-1 signaling pathway
|
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Signal amplification
|
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Platelet homeostasis
|
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MicroRNAs in cardiomyocyte hypertrophy
|
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Angiogenesis
|
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Physiological and Pathological Hypertrophy of the Heart
|
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Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
|
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Regulation of toll-like receptor signaling pathway
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| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6014). |
|---|
| REF 2 | J Med Chem. 2003 Jul 17;46(15):3230-44.Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. |
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