| Drug General Information |
| Drug ID |
D0XX5S
|
| Former ID |
DNC012248
|
| Drug Name |
DICHLOROISOPROTERENOL
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C11H15Cl2NO
|
| Canonical SMILES |
CC(C)NCC(C1=CC(=C(C=C1)Cl)Cl)O
|
| InChI |
1S/C11H15Cl2NO/c1-7(2)14-6-11(15)8-3-4-9(12)10(13)5-8/h3-5,7,11,14-15H,6H2,1-2H3
|
| InChIKey |
VKMGSWIFEHZQRS-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Beta-2 adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Beta-1 adrenergic receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
cGMP-PKG signaling pathway
|
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Endocytosis
|
|
Adrenergic signaling in cardiomyocytes
|
|
Salivary secretionhsa04020:Calcium signaling pathway
|
|
Gap junction
|
|
Salivary secretion
|
|
Dilated cardiomyopathy
|
|
NetPath Pathway
|
TCR Signaling Pathway
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Beta2 adrenergic receptor signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Beta1 adrenergic receptor signaling pathway
|
|
Pathway Interaction Database
|
Arf6 trafficking events
|
|
Arf6 signaling events
|
|
PathWhiz Pathway
|
Muscle/Heart Contraction
|
|
Reactome
|
Adrenoceptors
|
|
G alpha (s) signalling eventsR-HSA-390696:Adrenoceptors
|
|
G alpha (s) signalling events
|
|
WikiPathways
|
Monoamine GPCRs
|
|
Calcium Regulation in the Cardiac Cell
|
|
GPCRs, Class A Rhodopsin-like
|
|
Vitamin D Receptor Pathway
|
|
GPCR ligand binding
|
|
GPCR downstream signaling
|
|
GPCRs, OtherWP58:Monoamine GPCRs
|
|
Endothelin Pathways
|
| References |
| REF 1 | J Med Chem. 1994 May 13;37(10):1518-25.The [(methyloxy)imino]methyl moiety as a bioisoster of aryl. A novel class of completely aliphatic beta-adrenergic receptor antagonists. |
|---|
