Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0YB7F
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| Former ID |
DIB020458
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| Drug Name |
MT-II
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| Synonyms |
melanotan II; MTII
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C50H69N15O9
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| InChI |
InChI=1S/C50H69N15O9/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,70)(H,64,74)(H,65,69)(H4,52,53,56)/t35-,36-,37-,38+,39-,40-,41-/m0/s1
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| InChIKey |
JDKLPDJLXHXHNV-MFVUMRCOSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
14890081, 14939041, 16659180, 44423271, 50064256, 50112577, 57335280, 80867774, 93815086, 103481530, 104068740, 104121488, 104407428, 123389854, 134340245, 134343469, 135048952, 135652308, 137274328, 139116892, 142227675, 144240042, 152134073, 152344279, 152344459, 162177756, 162222552, 164828419, 184605715, 187072143, 227296747, 244119246, 249719041, 251915695, 251917045, 252156616, 252351544
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| Target and Pathway | |||||
| Target(s) | Melanocortin-4 receptor | Target Info | Agonist | [2] | |
| Melanocortin MC5 receptor | Target Info | Agonist | [3] | ||
| Melanocyte stimulating hormone receptor | Target Info | Agonist | [4] | ||
| Melanocortin-3 receptor | Target Info | Agonist | [5] | ||
| KEGG Pathway | Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction | ||||
| Melanogenesishsa04080:Neuroactive ligand-receptor interaction | |||||
| Pathway Interaction Database | Syndecan-3-mediated signaling events | ||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (s) signalling eventsR-HSA-375276:Peptide ligand-binding receptors | |||||
| G alpha (s) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1323). | ||||
| REF 2 | Molecular determinants of ligand binding to the human melanocortin-4 receptor. Biochemistry. 2000 Dec 5;39(48):14900-11. | ||||
| REF 3 | The role of melanocortins in body weight regulation: opportunities for the treatment of obesity. Eur J Pharmacol. 2002 Apr 12;440(2-3):141-57. | ||||
| REF 4 | Design of potent linear alpha-melanotropin 4-10 analogues modified in positions 5 and 10. J Med Chem. 1989 Jan;32(1):174-9. | ||||
| REF 5 | Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat. Eur J Pharmacol. 1999 Aug 13;378(3):249-58. | ||||
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