Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0Z6VR
|
||||
| Former ID |
DNC000357
|
||||
| Drug Name |
Buthionine sulfoximine
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Cancer; Malaria [ICD9: 140-229; ICD10:C00-C96, B54] | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C8H18N2O3S
|
||||
| Canonical SMILES |
CCCCS(=N)(=O)CCC(C(=O)[O-])[NH3+]
|
||||
| InChI |
1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)
|
||||
| InChIKey |
KJQFBVYMGADDTQ-UHFFFAOYSA-N
|
||||
| CAS Number |
CAS 83730-53-4
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Glutamate--cysteine ligase regulatorysubunit | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Glutathione metabolism | ||||
| Metabolic pathways | |||||
| PathWhiz Pathway | Glutamate Metabolism | ||||
| Glutathione Metabolism | |||||
| Cysteine Metabolism | |||||
| WikiPathways | Transcriptional activation by NRF2 | ||||
| NRF2 pathway | |||||
| Nuclear Receptors Meta-Pathway | |||||
| Metabolism of amino acids and derivatives | |||||
| Trans-sulfuration and one carbon metabolism | |||||
| Trans-sulfuration pathway | |||||
| Phase II conjugation | |||||
| Glutathione metabolism | |||||
| References | |||||
| REF 1 | Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. Epub 2007 Mar 6. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.