Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T99912
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| Former ID |
TTDR00950
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| Target Name |
Kynureninase
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| Gene Name |
KYNU
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| Synonyms |
L-kynurenine hydrolase; KYNU
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| Target Type |
Research
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| Function |
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
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| BioChemical Class |
Carbon-carbon bonds hydrolase
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| UniProt ID | |||||
| EC Number |
EC 3.7.1.3
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| Sequence |
MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLS
LVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLM KDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHG LNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAG QAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKP ALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKK SVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEK RGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN |
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| Inhibitor | 3,6,9,12,15-Pentaoxaheptadecane | Drug Info | [1] | ||
| 3-hydroxydesaminokynurenine | Drug Info | [2] | |||
| 3-Hydroxyhippuric acid | Drug Info | [1] | |||
| 3-methoxydesaminokynurenine | Drug Info | [2] | |||
| Pathways | |||||
| BioCyc Pathway | Superpathway of tryptophan utilization | ||||
| Tryptophan degradation | |||||
| L-kynurenine degradation | |||||
| Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde | |||||
| NAD de novo biosynthesis | |||||
| KEGG Pathway | Tryptophan metabolism | ||||
| Metabolic pathways | |||||
| NetPath Pathway | TSLP Signaling Pathway | ||||
| PathWhiz Pathway | Tryptophan Metabolism | ||||
| Reactome | Tryptophan catabolism | ||||
| WikiPathways | Tryptophan metabolism | ||||
| Metabolism of amino acids and derivatives | |||||
| NAD Biosynthesis II (from tryptophan) | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | ||||
| REF 2 | Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase. BMC Biochem. 2003 Sep 24;4:13. | ||||
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