Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0XU4Y
|
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| Former ID |
DNC011363
|
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| Drug Name |
NSC-66209
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C14H10O5
|
||||
| Canonical SMILES |
CC1=C2C=C(C(=O)C=C2OC3=CC(=C(C=C13)O)O)O
|
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| InChI |
1S/C14H10O5/c1-6-7-2-9(15)11(17)4-13(7)19-14-5-12(18)10(16)3-8(6)14/h2-5,15-17H,1H3
|
||||
| InChIKey |
TZVNNUHRZXQCHM-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Induced myeloid leukemia cell differentiation protein Mcl-1 | Target Info | Inhibitor | [1] | |
| Mannose-6-phosphate isomerase | Target Info | Inhibitor | [1] | ||
| KEGG Pathway | PI3K-Akt signaling pathway | ||||
| MicroRNAs in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Apoptosis signaling pathway | ||||
| CCKR signaling map ST | |||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| Direct p53 effectors | |||||
| IL6-mediated signaling events | |||||
| HIF-1-alpha transcription factor network | |||||
| WikiPathways | Apoptosis | ||||
| miR-targeted genes in muscle cell - TarBase | |||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| miR-targeted genes in leukocytes - TarBase | |||||
| Apoptosis Modulation and Signaling | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). | ||||
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