| Drug General Information |
| Drug ID |
D05BTF
|
| Former ID |
DNC009589
|
| Drug Name |
Tert-Butyl 5-(2-oxohexadecanamido)pentanoate
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C25H47NO4
|
| Canonical SMILES |
CCCCCCCCCCCCCCC(=O)C(=O)NCCCCC(=O)OC(C)(C)C
|
| InChI |
1S/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-19-22(27)24(29)26-21-18-17-20-23(28)30-25(2,3)4/h5-21H2,1-4H3,(H,26,29)
|
| InChIKey |
RXNGZFCASMDLGP-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Cytosolic phospholipase A2 |
Target Info |
Inhibitor |
[1]
|
|---|
|
BioCyc Pathway
|
Phospholipases
|
|
KEGG Pathway
|
Glycerophospholipid metabolism
|
|
Ether lipid metabolism
|
|
Arachidonic acid metabolism
|
|
Linoleic acid metabolism
|
|
alpha-Linolenic acid metabolism
|
|
Metabolic pathways
|
|
MAPK signaling pathway
|
|
Ras signaling pathway
|
|
Vascular smooth muscle contraction
|
|
VEGF signaling pathway
|
|
Platelet activation
|
|
Fc epsilon RI signaling pathway
|
|
Fc gamma R-mediated phagocytosis
|
|
Glutamatergic synapse
|
|
Serotonergic synapse
|
|
Long-term depression
|
|
Inflammatory mediator regulation of TRP channels
|
|
GnRH signaling pathway
|
|
Ovarian steroidogenesis
|
|
Oxytocin signaling pathway
|
|
Choline metabolism in cancer
|
|
NetPath Pathway
|
TCR Signaling Pathway
|
|
PANTHER Pathway
|
Angiogenesis
|
|
Endothelin signaling pathway
|
|
Inflammation mediated by chemokine and cytokine signaling pathway
|
|
Oxidative stress response
|
|
VEGF signaling pathway
|
|
CCKR signaling map ST
|
|
Pathway Interaction Database
|
Fc-epsilon receptor I signaling in mast cells
|
|
Endothelins
|
|
PDGFR-beta signaling pathway
|
|
Signaling mediated by p38-alpha and p38-beta
|
|
PathWhiz Pathway
|
Fc Epsilon Receptor I Signaling in Mast Cells
|
|
Reactome
|
Acyl chain remodelling of PC
|
|
Acyl chain remodelling of PE
|
|
Acyl chain remodelling of PI
|
|
ADP signalling through P2Y purinoceptor 1
|
|
Platelet sensitization by LDL
|
|
WikiPathways
|
Prostaglandin Synthesis and Regulation
|
|
p38 MAPK Signaling Pathway
|
|
Glycerophospholipid biosynthesis
|
|
Arachidonic acid metabolism
|
|
PDGF Pathway
|
|
Integrated Pancreatic Cancer Pathway
|
|
AGE/RAGE pathway
|
|
Opioid Signalling
|
|
Signal amplification
|
|
Platelet homeostasis
|
| References |
| REF 1 | Bioorg Med Chem. 2008 Dec 15;16(24):10257-69. Epub 2008 Nov 1.Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2)enzymes. |
|---|
